78637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4152047..4152687 Replicon chromosome
Accession NZ_CP022181
Organism Aeromonas salmonicida strain S44

Toxin (Protein)


Gene name vagD Uniprot ID A0A807Z4U5
Locus tag CE463_RS21480 Protein ID WP_005320982.1
Coordinates 4152274..4152687 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A807Z5T0
Locus tag CE463_RS21475 Protein ID WP_005320985.1
Coordinates 4152047..4152277 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE463_RS21455 4148023..4149414 + 1392 WP_034283822.1 T3SS effector protein-tyrosine-phosphatase AopH -
CE463_RS21460 4149487..4149888 - 402 Protein_3755 IS4 family transposase -
CE463_RS21465 4149956..4150873 + 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
CE463_RS24665 4151290..4151679 + 390 WP_139403308.1 site-specific integrase -
CE463_RS21470 4151592..4151978 + 387 WP_017413139.1 tyrosine-type recombinase/integrase -
CE463_RS21475 4152047..4152277 + 231 WP_005320985.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CE463_RS21480 4152274..4152687 + 414 WP_005320982.1 PIN domain-containing protein Toxin
CE463_RS21485 4152762..4153128 + 367 Protein_3761 hypothetical protein -
CE463_RS21490 4153144..4153419 + 276 Protein_3762 hypothetical protein -
CE463_RS21495 4153477..4154394 - 918 WP_076611341.1 IS5-like element ISAs4 family transposase -
CE463_RS21500 4154629..4155546 - 918 WP_088814123.1 IS5-like element ISAs4 family transposase -
CE463_RS21505 4155733..4156314 - 582 Protein_3765 subclass B2 metallo-beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - aerA/act / aopH 4139512..4155546 16034
- inside IScluster/Tn - aopH 4140074..4157782 17708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14935.23 Da        Isoelectric Point: 5.7146

>T78637 WP_005320982.1 NZ_CP022181:4152274-4152687 [Aeromonas salmonicida]
VKTFMLDTCICSFIMREMPQSVLERLGAEVASGNRIVISAITYAEMRYGQIGKKASPKLGPAIDEFVRRLDGILPWDAAT
VDQTLEVRQQLAALGTPIGNNDAAIAAHALTAGCVLVTNNTREFSRVAGLLYEDWVH

Download         Length: 414 bp

>T78637 NZ_CP022181:4152274-4152687 [Aeromonas salmonicida]
GTGAAGACGTTTATGCTCGATACCTGCATTTGTTCCTTCATCATGCGCGAAATGCCACAGTCAGTTCTTGAACGGTTGGG
CGCAGAGGTGGCGAGCGGCAATCGGATTGTGATCTCGGCAATCACCTACGCCGAAATGCGTTATGGCCAGATCGGCAAGA
AGGCTTCTCCGAAGCTGGGGCCAGCCATTGATGAATTTGTTCGTCGTCTCGATGGGATCTTGCCATGGGACGCTGCTACG
GTCGATCAGACGCTCGAAGTGCGCCAGCAGTTAGCAGCCTTGGGCACTCCGATCGGCAATAACGATGCTGCTATTGCCGC
CCACGCCCTGACGGCTGGCTGTGTACTGGTAACCAACAATACCCGCGAGTTTTCCCGAGTGGCGGGGCTGCTCTATGAAG
ACTGGGTTCACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8699.88 Da        Isoelectric Point: 4.7419

>AT78637 WP_005320985.1 NZ_CP022181:4152047-4152277 [Aeromonas salmonicida]
MRTVSIFKNGKNQAVRLPKDMEFQGVNDLEIIKNGDTITLRPARPDWFSLAECQKVDADFLQERTDVISDEGRFAL

Download         Length: 231 bp

>AT78637 NZ_CP022181:4152047-4152277 [Aeromonas salmonicida]
ATGCGTACTGTATCAATTTTTAAAAATGGTAAAAATCAGGCGGTGAGACTGCCAAAAGACATGGAGTTTCAGGGGGTTAA
TGACCTTGAGATTATCAAAAATGGCGACACAATCACGTTGCGCCCGGCCCGCCCTGATTGGTTTTCCCTGGCGGAATGCC
AGAAGGTGGATGCAGATTTCTTGCAAGAACGTACCGATGTGATCAGCGATGAAGGACGGTTCGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807Z4U5

Antitoxin

Source ID Structure
AlphaFold DB A0A807Z5T0

References