78635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 53046..54399 Replicon plasmid pS44-2
Accession NZ_CP022177
Organism Aeromonas salmonicida strain S44

Toxin (Protein)


Gene name sanaT Uniprot ID A0A807ZF23
Locus tag CE463_RS01420 Protein ID WP_042468256.1
Coordinates 53434..54399 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag CE463_RS01415 Protein ID WP_042468273.1
Coordinates 53046..53444 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE463_RS01405 51261..51623 - 363 WP_042468258.1 hypothetical protein -
CE463_RS01410 51663..52109 - 447 WP_042468257.1 DNA repair protein RadC -
CE463_RS01415 53046..53444 + 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
CE463_RS01420 53434..54399 + 966 WP_042468256.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CE463_RS01425 54445..54810 + 366 WP_042468255.1 hypothetical protein -
CE463_RS01430 54829..55326 + 498 WP_042468254.1 hypothetical protein -
CE463_RS01440 55834..55986 + 153 WP_042468253.1 Hok/Gef family protein -
CE463_RS01445 56151..56333 + 183 WP_042468252.1 hypothetical protein -
CE463_RS01450 56439..57401 - 963 WP_088814090.1 reverse transcriptase family protein -
CE463_RS01455 57376..57687 - 312 WP_042468251.1 helix-turn-helix domain-containing protein -
CE463_RS01460 58450..58697 - 248 Protein_63 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70841 70841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36419.60 Da        Isoelectric Point: 5.4150

>T78635 WP_042468256.1 NZ_CP022177:53434-54399 [Aeromonas salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I

Download         Length: 966 bp

>T78635 NZ_CP022177:53434-54399 [Aeromonas salmonicida]
ATGCAGCCTAAAGACTCTTCGATTTTCGCCGACGTTTCTGACTACTTCGGGATCGATAACCCTGCGATAGCAGAAAAGGA
CTACTACGTCGTCCAGCTGCTCAAACTGCTTGCAAGTCATTCTTGCCAGCACCACACCATGGTGTTTGCAGGCGGGACCG
CATTAGCCAAAGCTGACGTCAAGCTTCAGCGCATGTCTGAAGATGTCGACATCAAGTTATCTGTTAACGATAGTGCTAAA
GATGAATCTCGAAGCGCGATGAAGCGCCATCGCAAAGCCATCCGAGATGGTTTGATTGAAGAGCTCAATGCGACTGGCGT
TTTCCAAGTAGAGAAGGCTGAGGTCATTTGTCGGGATGAGCACAGGTACATTGAAATGCCGGTGAGATACCCGCAGGCCT
TCAGCAAGGCCCCCTGCCTTCGGCCTTTCATCAAGCTCGAACTCATTGAGACTGATCTGCTTGCAGGCCATAACCCCATG
CCCATTTGTTCGCTGCACAATGAAGCGATGCAGCAAGAACCTGAAGTGCCAGCCTTCAACACGGTTCCCCTGATCTCCAC
CCAAGCCGAGAAAGTGTTGTCGATGCTGCGCAGAACAGCCAGCGTCAAGCATGACCCAGAACGATTGGATGATGAGTCGT
TGGTTCGCCACATTTATGACACTTATCGCCTGCAACAAAGTACCACCTTTGATTTGGCCGAACTGGCAGGGCTGATAGCT
GAAGGGATGAAGATGGATCGTGATCGCTATGGTCCCCAACACCCCGAGTTTGCAGCAGATCCTATCGGTGTGATGCGGTT
TGGCCTGGATGTGATTGCTGGTGACCCCCTATACAAAGATCGTTATGAGGCATTCGTGAAGCCGATGGTGTATGGGGATG
CGTTGACTTGGGATGAGGCATTTCGCGTGTTCGAGGCTGTTGCGCGCCAGGCTCTAGATCACATTGAGCAACACAAACTT
ATTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT78635 WP_042468273.1 NZ_CP022177:53046-53444 [Aeromonas salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT78635 NZ_CP022177:53046-53444 [Aeromonas salmonicida]
ATGACCATTGCAGACCGTGTTGAAGCACGAATCAAACGATCTAAGCGAGATGTGTTTCTCCGTGAGGATTTCGATGACTT
GGGCGGTTATGACCAAATAGGCAGAGCCTTACGCCAGATGTGTGAAAAGGGTCTGCTTCTGAAGGTCGGCTACGGCGTGT
ATGCAAAGGCACGGCGTAACCGGATCAATAGTCGCTTGATGATCGCCTCCCCTGGAGGTCCAGACGCCGTACTCATTGCT
ACGCTTGACCGCCTGAAGGTGCCTTACGAACTGAAGGGCCTGACCGCAGCTTATGCCGCGGGGAAATCCACTCAGGTTCC
CGCCTTTATGGAAGTTAAGCCTAAAAAGCGTTTTTCCAGAAAGCTGAAAATAGGAAGCCGAGTGTTCAATGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZF23

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References