Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 125627..127186 | Replicon | plasmid pS44-1 |
Accession | NZ_CP022176 | ||
Organism | Aeromonas salmonicida strain S44 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A806XZ83 |
Locus tag | CE463_RS00650 | Protein ID | WP_047235025.1 |
Coordinates | 125882..127186 (+) | Length | 435 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A189PGR7 |
Locus tag | CE463_RS00645 | Protein ID | WP_011899353.1 |
Coordinates | 125627..125878 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CE463_RS00620 | 120773..121618 | - | 846 | WP_073536960.1 | hypothetical protein | - |
CE463_RS00625 | 121631..122581 | - | 951 | WP_005342491.1 | IS1595-like element ISKpn3 family transposase | - |
CE463_RS00630 | 122642..123295 | - | 654 | WP_073536961.1 | hypothetical protein | - |
CE463_RS00635 | 123874..124404 | + | 531 | WP_047235027.1 | hypothetical protein | - |
CE463_RS00640 | 124407..125411 | + | 1005 | WP_047235026.1 | tyrosine-type recombinase/integrase | - |
CE463_RS00645 | 125627..125878 | + | 252 | WP_011899353.1 | XRE family transcriptional regulator | Antitoxin |
CE463_RS00650 | 125882..127186 | + | 1305 | WP_047235025.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
CE463_RS00655 | 127191..127685 | + | 495 | WP_059296301.1 | hypothetical protein | - |
CE463_RS00660 | 127908..129314 | + | 1407 | WP_088821984.1 | PAAR domain-containing protein | - |
CE463_RS00665 | 129343..130203 | + | 861 | Protein_127 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
CE463_RS00670 | 130216..130758 | + | 543 | WP_000587837.1 | AAA family ATPase | - |
CE463_RS00675 | 131240..131431 | - | 192 | WP_000951934.1 | hypothetical protein | - |
CE463_RS00680 | 131455..131682 | + | 228 | WP_000248278.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(3)-IId / aph(3'')-Ib / aph(6)-Id / dfrA5 / qacE / sul1 / qnrVC6 / floR / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / mph(A) / aph(3')-Ia | - | 1..216870 | 216870 | |
- | flank | IS/Tn | - | - | 121631..122581 | 950 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 435 a.a. Molecular weight: 48087.16 Da Isoelectric Point: 6.6364
>T78634 WP_047235025.1 NZ_CP022176:125882-127186 [Aeromonas salmonicida]
MRAQQLIVAMNGEVVGTLYRAGNGAMSFQYTPEWVAEPGSRPLSLSLPLGHSRIRGSEVFNFFSNLLPDSEAIIARMQAR
FHVETAHPFDLLASVGRDCVGAIQLYPPGIDIPPVTETLAEPLEDAQIEQLLEGYQVAPLGMAEDVDFRISIAGAQEKTA
LLWHQGRWQRPQGSTPTSHIFKLPIGRIVQNNIDLRDSCENEWLCLRIAKAFGFDVANADLAAFGQKRVLIVERFDRRWS
RNGEWLLRLPQEDFCQAMGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNYSIFIEP
ASSFRMTPIYDVMSAFPIFESGGIAAQKAKMAMALQGKNKQYHFAMIQPRHFISTAAHVGFSPDRATRLMHEMAADTESV
ISAVTAELPADFPEHISNAIFQGLSSQAARIMRG
MRAQQLIVAMNGEVVGTLYRAGNGAMSFQYTPEWVAEPGSRPLSLSLPLGHSRIRGSEVFNFFSNLLPDSEAIIARMQAR
FHVETAHPFDLLASVGRDCVGAIQLYPPGIDIPPVTETLAEPLEDAQIEQLLEGYQVAPLGMAEDVDFRISIAGAQEKTA
LLWHQGRWQRPQGSTPTSHIFKLPIGRIVQNNIDLRDSCENEWLCLRIAKAFGFDVANADLAAFGQKRVLIVERFDRRWS
RNGEWLLRLPQEDFCQAMGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNYSIFIEP
ASSFRMTPIYDVMSAFPIFESGGIAAQKAKMAMALQGKNKQYHFAMIQPRHFISTAAHVGFSPDRATRLMHEMAADTESV
ISAVTAELPADFPEHISNAIFQGLSSQAARIMRG
Download Length: 1305 bp
>T78634 NZ_CP022176:125882-127186 [Aeromonas salmonicida]
ATGAGAGCGCAGCAGCTGATAGTGGCAATGAACGGCGAGGTTGTGGGCACATTGTACCGAGCTGGCAACGGAGCCATGTC
ATTCCAATACACGCCGGAATGGGTCGCAGAACCAGGTTCTCGTCCGCTATCCCTCTCACTACCTCTGGGCCATAGCCGGA
TTAGAGGAAGTGAAGTCTTCAATTTTTTTAGCAACCTTCTGCCCGACTCCGAGGCGATCATTGCTAGGATGCAGGCCCGG
TTTCACGTTGAGACAGCACACCCCTTTGATCTGTTGGCTAGTGTCGGCCGAGATTGTGTTGGCGCTATCCAACTCTACCC
GCCCGGTATCGATATCCCTCCTGTCACGGAGACGCTTGCAGAGCCACTGGAAGATGCACAGATTGAGCAGTTGCTGGAAG
GCTATCAGGTGGCACCACTTGGTATGGCTGAGGATGTAGACTTTCGGATCTCGATTGCCGGTGCCCAAGAAAAGACGGCA
TTGCTTTGGCACCAAGGGCGCTGGCAGCGACCGCAGGGCAGCACCCCGACAAGTCATATCTTCAAGCTTCCCATCGGTCG
GATCGTACAAAACAACATCGACCTCCGAGACAGTTGCGAGAATGAATGGCTCTGCCTGCGGATCGCAAAGGCATTTGGCT
TTGACGTTGCCAATGCCGACTTGGCCGCATTTGGCCAAAAGCGTGTGCTGATCGTAGAGCGGTTCGATAGACGTTGGTCG
AGAAACGGTGAATGGTTGTTGCGGTTGCCTCAGGAAGATTTTTGCCAGGCGATGGGGATCGCCCCGGCTCTGAAATACGA
GTCCCATGGTGGCCCCGGCATTGCTGATGCTATGAAGTTGTTGTTGGGTTCCCGGCTAGCAGCCAAGGATAGAGAACAGT
TCTTCAAATCGCAGATCCTGTTCTGGATGTTGGCGGCGATCGATGGGCACGGCAAGAACTACAGCATCTTCATCGAGCCT
GCGTCGTCGTTCAGGATGACCCCCATCTATGATGTCATGTCAGCCTTTCCGATCTTCGAAAGCGGTGGCATTGCAGCTCA
AAAGGCCAAAATGGCGATGGCACTCCAAGGGAAAAATAAGCAGTACCACTTTGCAATGATACAGCCGCGTCACTTCATCA
GTACCGCTGCTCATGTGGGTTTTTCACCGGATAGAGCTACTCGACTTATGCACGAGATGGCTGCTGACACCGAATCGGTG
ATCTCGGCCGTAACTGCTGAGTTGCCAGCCGATTTCCCTGAGCACATCAGCAATGCCATTTTCCAAGGGCTATCCAGCCA
GGCTGCAAGGATTATGAGGGGGTAA
ATGAGAGCGCAGCAGCTGATAGTGGCAATGAACGGCGAGGTTGTGGGCACATTGTACCGAGCTGGCAACGGAGCCATGTC
ATTCCAATACACGCCGGAATGGGTCGCAGAACCAGGTTCTCGTCCGCTATCCCTCTCACTACCTCTGGGCCATAGCCGGA
TTAGAGGAAGTGAAGTCTTCAATTTTTTTAGCAACCTTCTGCCCGACTCCGAGGCGATCATTGCTAGGATGCAGGCCCGG
TTTCACGTTGAGACAGCACACCCCTTTGATCTGTTGGCTAGTGTCGGCCGAGATTGTGTTGGCGCTATCCAACTCTACCC
GCCCGGTATCGATATCCCTCCTGTCACGGAGACGCTTGCAGAGCCACTGGAAGATGCACAGATTGAGCAGTTGCTGGAAG
GCTATCAGGTGGCACCACTTGGTATGGCTGAGGATGTAGACTTTCGGATCTCGATTGCCGGTGCCCAAGAAAAGACGGCA
TTGCTTTGGCACCAAGGGCGCTGGCAGCGACCGCAGGGCAGCACCCCGACAAGTCATATCTTCAAGCTTCCCATCGGTCG
GATCGTACAAAACAACATCGACCTCCGAGACAGTTGCGAGAATGAATGGCTCTGCCTGCGGATCGCAAAGGCATTTGGCT
TTGACGTTGCCAATGCCGACTTGGCCGCATTTGGCCAAAAGCGTGTGCTGATCGTAGAGCGGTTCGATAGACGTTGGTCG
AGAAACGGTGAATGGTTGTTGCGGTTGCCTCAGGAAGATTTTTGCCAGGCGATGGGGATCGCCCCGGCTCTGAAATACGA
GTCCCATGGTGGCCCCGGCATTGCTGATGCTATGAAGTTGTTGTTGGGTTCCCGGCTAGCAGCCAAGGATAGAGAACAGT
TCTTCAAATCGCAGATCCTGTTCTGGATGTTGGCGGCGATCGATGGGCACGGCAAGAACTACAGCATCTTCATCGAGCCT
GCGTCGTCGTTCAGGATGACCCCCATCTATGATGTCATGTCAGCCTTTCCGATCTTCGAAAGCGGTGGCATTGCAGCTCA
AAAGGCCAAAATGGCGATGGCACTCCAAGGGAAAAATAAGCAGTACCACTTTGCAATGATACAGCCGCGTCACTTCATCA
GTACCGCTGCTCATGTGGGTTTTTCACCGGATAGAGCTACTCGACTTATGCACGAGATGGCTGCTGACACCGAATCGGTG
ATCTCGGCCGTAACTGCTGAGTTGCCAGCCGATTTCCCTGAGCACATCAGCAATGCCATTTTCCAAGGGCTATCCAGCCA
GGCTGCAAGGATTATGAGGGGGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9290.61 Da Isoelectric Point: 7.2047
>AT78634 WP_011899353.1 NZ_CP022176:125627-125878 [Aeromonas salmonicida]
MKVTSPASLASAIRDHRKVSKLTQKDAAALVGIKQATVSDFENRPESTKLETLFKILAALDLELHVVKRGSTLDEEQAWD
REW
MKVTSPASLASAIRDHRKVSKLTQKDAAALVGIKQATVSDFENRPESTKLETLFKILAALDLELHVVKRGSTLDEEQAWD
REW
Download Length: 252 bp
>AT78634 NZ_CP022176:125627-125878 [Aeromonas salmonicida]
ATGAAGGTTACATCTCCAGCCTCTCTGGCTTCTGCTATCCGCGACCATCGCAAGGTCAGTAAACTGACGCAGAAAGATGC
TGCGGCATTGGTTGGGATTAAGCAGGCGACAGTCTCAGATTTTGAGAACCGGCCTGAGTCTACCAAGCTGGAGACGCTAT
TCAAGATCCTTGCTGCACTGGATCTGGAGCTTCATGTGGTTAAGCGGGGCTCTACCCTGGATGAGGAGCAAGCTTGGGAT
AGGGAGTGGTAA
ATGAAGGTTACATCTCCAGCCTCTCTGGCTTCTGCTATCCGCGACCATCGCAAGGTCAGTAAACTGACGCAGAAAGATGC
TGCGGCATTGGTTGGGATTAAGCAGGCGACAGTCTCAGATTTTGAGAACCGGCCTGAGTCTACCAAGCTGGAGACGCTAT
TCAAGATCCTTGCTGCACTGGATCTGGAGCTTCATGTGGTTAAGCGGGGCTCTACCCTGGATGAGGAGCAAGCTTGGGAT
AGGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806XZ83 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A189PGR7 |