78631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 23638..24991 Replicon plasmid pS121-2
Accession NZ_CP022171
Organism Aeromonas salmonicida strain S121

Toxin (Protein)


Gene name sanaT Uniprot ID A0A807ZF23
Locus tag CE456_RS01210 Protein ID WP_042468256.1
Coordinates 23638..24603 (-) Length 322 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A807ZF76
Locus tag CE456_RS01215 Protein ID WP_042468273.1
Coordinates 24593..24991 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CE456_RS01170 19341..19588 + 248 Protein_19 hypothetical protein -
CE456_RS01175 20350..20661 + 312 WP_042468251.1 helix-turn-helix domain-containing protein -
CE456_RS01180 20636..21598 + 963 WP_088814090.1 reverse transcriptase family protein -
CE456_RS01185 21704..21886 - 183 WP_042468252.1 hypothetical protein -
CE456_RS01190 22051..22203 - 153 WP_042468253.1 Hok/Gef family protein -
CE456_RS01200 22711..23208 - 498 WP_042468254.1 hypothetical protein -
CE456_RS01205 23227..23592 - 366 WP_042468255.1 hypothetical protein -
CE456_RS01210 23638..24603 - 966 WP_042468256.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CE456_RS01215 24593..24991 - 399 WP_042468273.1 S-adenosylhomocysteine hydrolase Antitoxin
CE456_RS01220 25928..26374 + 447 WP_042468257.1 DNA repair protein RadC -
CE456_RS01225 26414..26776 + 363 WP_042468258.1 hypothetical protein -
CE456_RS01240 28127..29104 + 978 WP_088814091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..70855 70855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 36419.60 Da        Isoelectric Point: 5.4150

>T78631 WP_042468256.1 NZ_CP022171:c24603-23638 [Aeromonas salmonicida]
MQPKDSSIFADVSDYFGIDNPAIAEKDYYVVQLLKLLASHSCQHHTMVFAGGTALAKADVKLQRMSEDVDIKLSVNDSAK
DESRSAMKRHRKAIRDGLIEELNATGVFQVEKAEVICRDEHRYIEMPVRYPQAFSKAPCLRPFIKLELIETDLLAGHNPM
PICSLHNEAMQQEPEVPAFNTVPLISTQAEKVLSMLRRTASVKHDPERLDDESLVRHIYDTYRLQQSTTFDLAELAGLIA
EGMKMDRDRYGPQHPEFAADPIGVMRFGLDVIAGDPLYKDRYEAFVKPMVYGDALTWDEAFRVFEAVARQALDHIEQHKL
I

Download         Length: 966 bp

>T78631 NZ_CP022171:c24603-23638 [Aeromonas salmonicida]
ATGCAGCCTAAAGACTCTTCGATTTTCGCCGACGTTTCTGACTACTTCGGGATCGATAACCCTGCGATAGCAGAAAAGGA
CTACTACGTCGTCCAGCTGCTCAAACTGCTTGCAAGTCATTCTTGCCAGCACCACACCATGGTGTTTGCAGGCGGGACCG
CATTAGCCAAAGCTGACGTCAAGCTTCAGCGCATGTCTGAAGATGTCGACATCAAGTTATCTGTTAACGATAGTGCTAAA
GATGAATCTCGAAGCGCGATGAAGCGCCATCGCAAAGCCATCCGAGATGGTTTGATTGAAGAGCTCAATGCGACTGGCGT
TTTCCAAGTAGAGAAGGCTGAGGTCATTTGTCGGGATGAGCACAGGTACATTGAAATGCCGGTGAGATACCCGCAGGCCT
TCAGCAAGGCCCCCTGCCTTCGGCCTTTCATCAAGCTCGAACTCATTGAGACTGATCTGCTTGCAGGCCATAACCCCATG
CCCATTTGTTCGCTGCACAATGAAGCGATGCAGCAAGAACCTGAAGTGCCAGCCTTCAACACGGTTCCCCTGATCTCCAC
CCAAGCCGAGAAAGTGTTGTCGATGCTGCGCAGAACAGCCAGCGTCAAGCATGACCCAGAACGATTGGATGATGAGTCGT
TGGTTCGCCACATTTATGACACTTATCGCCTGCAACAAAGTACCACCTTTGATTTGGCCGAACTGGCAGGGCTGATAGCT
GAAGGGATGAAGATGGATCGTGATCGCTATGGTCCCCAACACCCCGAGTTTGCAGCAGATCCTATCGGTGTGATGCGGTT
TGGCCTGGATGTGATTGCTGGTGACCCCCTATACAAAGATCGTTATGAGGCATTCGTGAAGCCGATGGTGTATGGGGATG
CGTTGACTTGGGATGAGGCATTTCGCGTGTTCGAGGCTGTTGCGCGCCAGGCTCTAGATCACATTGAGCAACACAAACTT
ATTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14761.36 Da        Isoelectric Point: 11.0142

>AT78631 WP_042468273.1 NZ_CP022171:c24991-24593 [Aeromonas salmonicida]
MTIADRVEARIKRSKRDVFLREDFDDLGGYDQIGRALRQMCEKGLLLKVGYGVYAKARRNRINSRLMIASPGGPDAVLIA
TLDRLKVPYELKGLTAAYAAGKSTQVPAFMEVKPKKRFSRKLKIGSRVFNAA

Download         Length: 399 bp

>AT78631 NZ_CP022171:c24991-24593 [Aeromonas salmonicida]
ATGACCATTGCAGACCGTGTTGAAGCACGAATCAAACGATCTAAGCGAGATGTGTTTCTCCGTGAGGATTTCGATGACTT
GGGCGGTTATGACCAAATAGGCAGAGCCTTACGCCAGATGTGTGAAAAGGGTCTGCTTCTGAAGGTCGGCTACGGCGTGT
ATGCAAAGGCACGGCGTAACCGGATCAATAGTCGCTTGATGATCGCCTCCCCTGGAGGTCCAGACGCCGTACTCATTGCT
ACGCTTGACCGCCTGAAGGTGCCTTACGAACTGAAGGGCCTGACCGCAGCTTATGCCGCGGGGAAATCCACTCAGGTTCC
CGCCTTTATGGAAGTTAAGCCTAAAAAGCGTTTTTCCAGAAAGCTGAAAATAGGAAGCCGAGTGTTCAATGCAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZF23

Antitoxin

Source ID Structure
AlphaFold DB A0A807ZF76

References