Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 86234..86753 Replicon plasmid pABWA45_1
Accession NZ_CP022155
Organism Escherichia coli strain ABWA45

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag CES94_RS27370 Protein ID WP_000277490.1
Coordinates 86234..86518 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag CES94_RS27375 Protein ID WP_000124732.1
Coordinates 86511..86753 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES94_RS27330 81932..82954 - 1023 WP_000361404.1 helicase UvrD -
CES94_RS27335 82939..83823 - 885 Protein_104 AAA family ATPase -
CES94_RS27340 83877..84582 - 706 Protein_105 IS6-like element IS26 family transposase -
CES94_RS27350 84645..85166 + 522 Protein_106 glucose-1-phosphate adenylyltransferase -
CES94_RS29715 85166..85498 + 333 Protein_107 glycogen/starch synthase -
CES94_RS27365 86004..86096 + 93 Protein_108 DNA partition complex ParG -
CES94_RS27370 86234..86518 - 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CES94_RS27375 86511..86753 - 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CES94_RS27380 87326..88120 - 795 Protein_111 replication initiator protein RepA -
CES94_RS27385 88156..90090 - 1935 Protein_112 Tn3 family transposase -
CES94_RS27390 90152..90856 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
CES94_RS27400 90918..91028 - 111 Protein_114 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..145220 145220
- inside IScluster/Tn - - 57322..90856 33534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T78595 WP_000277490.1 NZ_CP022155:c86518-86234 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T78595 NZ_CP022155:c86518-86234 [Escherichia coli]
GTGTATAAACTCACTGAACGGGCAGCAGACGACTTCGCCGGGATTTATGACTATACGCTCTTGAAATTTGGTGAAGCTCA
GGCAGACCATTATACAGACGCACTTGAGGCATTTTTCGAGACACTGGCCGGAATGCCAGATATGGGACGTGACTACCATA
CCGTTCCTGGTGTGATGCGCATTGAATTTCAGCGACATGCCATTTTTTATACGGTTCGTGATACGGATATTCTGATTGCG
CGTATTTTGCACCAACAGATGAACCATAAACGCCATTTACTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT78595 WP_000124732.1 NZ_CP022155:c86753-86511 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT78595 NZ_CP022155:c86753-86511 [Escherichia coli]
ATGGCCAGAACAACAAGCGTTACGATTGGCGAACAACTCGATTCGTTTATTAGTCGATTAATAGACAGTGGCCGTTACGG
CTCTGCGAGTGAAGTTATGCGTTCTGCGCTGCGATTGCTGGAGCAACAGGAAACAAACGATGAAGTTATTCGTCAGGCTG
TTATTGCTGGGCTGGAAAGCGGTGAAAGCTCGCTATCACTGCGGGATATTGCAGCACAAAGAAAACTGAGACATCGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References