Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4153610..4154397 Replicon chromosome
Accession NZ_CP022154
Organism Escherichia coli strain ABWA45

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CES94_RS21915 Protein ID WP_060659227.1
Coordinates 4153610..4153987 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CES94_RS21920 Protein ID WP_060659226.1
Coordinates 4154038..4154397 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES94_RS21875 4148853..4149608 - 756 WP_001052721.1 hydroxyacylglutathione hydrolase -
CES94_RS21880 4149642..4150364 + 723 WP_001295200.1 class I SAM-dependent methyltransferase -
CES94_RS21885 4150361..4150828 - 468 WP_000917883.1 ribonuclease HI -
CES94_RS21890 4150893..4151624 + 732 WP_001300756.1 DNA polymerase III subunit epsilon -
CES94_RS21900 4151955..4152806 - 852 WP_060659228.1 DUF4942 domain-containing protein -
CES94_RS21905 4152887..4153090 - 204 WP_060615262.1 DUF957 domain-containing protein -
CES94_RS21910 4153122..4153613 - 492 WP_060615263.1 hypothetical protein -
CES94_RS21915 4153610..4153987 - 378 WP_060659227.1 TA system toxin CbtA family protein Toxin
CES94_RS21920 4154038..4154397 - 360 WP_060659226.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CES94_RS21925 4154421..4154642 - 222 WP_044068431.1 DUF987 domain-containing protein -
CES94_RS21930 4154663..4155142 - 480 WP_060659225.1 DNA repair protein RadC -
CES94_RS21935 4155154..4155624 - 471 WP_053271697.1 antirestriction protein -
CES94_RS21945 4155892..4156710 - 819 WP_060659224.1 DUF945 domain-containing protein -
CES94_RS21950 4156830..4157063 - 234 WP_001614358.1 DUF905 domain-containing protein -
CES94_RS21955 4157140..4157589 - 450 WP_040220400.1 hypothetical protein -
CES94_RS21960 4157586..4158038 - 453 WP_001020418.1 hypothetical protein -
CES94_RS21965 4158074..4158709 - 636 WP_000772020.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14152.91 Da        Isoelectric Point: 6.9778

>T78588 WP_060659227.1 NZ_CP022154:c4153987-4153610 [Escherichia coli]
MQTQPLSSTQEATSRPSPVEIWQQLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR

Download         Length: 378 bp

>T78588 NZ_CP022154:c4153987-4153610 [Escherichia coli]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACAGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13139.07 Da        Isoelectric Point: 7.0261

>AT78588 WP_060659226.1 NZ_CP022154:c4154397-4154038 [Escherichia coli]
MSNKTPIVNHDVTEPWWGLKRSITPCFGVRLVQAGNCLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT78588 NZ_CP022154:c4154397-4154038 [Escherichia coli]
TTGTCGAATAAAACACCGATAGTAAACCACGATGTCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGTACGGCTGGTGCAGGCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
CGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References