Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4421190..4421847 Replicon chromosome
Accession NZ_CP022148
Organism Enterobacter roggenkampii strain 704SK10

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag CES92_RS21610 Protein ID WP_021242050.1
Coordinates 4421437..4421847 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag CES92_RS21605 Protein ID WP_006178375.1
Coordinates 4421190..4421456 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES92_RS21585 4416624..4418057 - 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -
CES92_RS21590 4418174..4418905 - 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
CES92_RS21595 4419171..4419830 + 660 WP_008499713.1 hemolysin III family protein -
CES92_RS21600 4419915..4420895 - 981 WP_063418236.1 tRNA-modifying protein YgfZ -
CES92_RS21605 4421190..4421456 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
CES92_RS21610 4421437..4421847 + 411 WP_021242050.1 protein YgfX Toxin
CES92_RS21615 4421854..4422375 - 522 WP_008499710.1 flavodoxin FldB -
CES92_RS21620 4422477..4423373 + 897 WP_063418237.1 site-specific tyrosine recombinase XerD -
CES92_RS21625 4423402..4424115 + 714 WP_063418238.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CES92_RS21630 4424121..4425854 + 1734 WP_063418239.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T78558 WP_021242050.1 NZ_CP022148:4421437-4421847 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T78558 NZ_CP022148:4421437-4421847 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAAATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT78558 WP_006178375.1 NZ_CP022148:4421190-4421456 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT78558 NZ_CP022148:4421190-4421456 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References