Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2459537..2460157 Replicon chromosome
Accession NZ_CP022148
Organism Enterobacter roggenkampii strain 704SK10

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag CES92_RS12150 Protein ID WP_008499287.1
Coordinates 2459939..2460157 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag CES92_RS12145 Protein ID WP_008499288.1
Coordinates 2459537..2459911 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CES92_RS12135 2454665..2455858 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CES92_RS12140 2455881..2459027 + 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
CES92_RS12145 2459537..2459911 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
CES92_RS12150 2459939..2460157 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
CES92_RS12155 2460364..2460915 + 552 WP_021241634.1 maltose O-acetyltransferase -
CES92_RS12160 2461033..2461500 + 468 WP_008499285.1 membrane protein -
CES92_RS12165 2461472..2462932 - 1461 WP_063418458.1 PLP-dependent aminotransferase family protein -
CES92_RS12170 2463034..2463744 + 711 WP_063418459.1 GNAT family N-acetyltransferase -
CES92_RS12175 2463741..2463881 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CES92_RS12180 2463884..2464144 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T78554 WP_008499287.1 NZ_CP022148:2459939-2460157 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T78554 NZ_CP022148:2459939-2460157 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT78554 WP_008499288.1 NZ_CP022148:2459537-2459911 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT78554 NZ_CP022148:2459537-2459911 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTTGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References