Detailed information of TA system TA078552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1578347..1579086
• Replicon: chromosome
• Accession: NZ_CP022148
• Organism: Enterobacter roggenkampii strain 704SK10

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A9E6WPH7
• Locus tag: CES92_RS07660
• Protein ID: WP_013087269.1
• Coordinates: 1578601..1579086 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A9E6WPN8
• Locus tag: CES92_RS07655
• Protein ID: WP_007869691.1
• Coordinates: 1578347..1578613 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CES92_RS07625	1574233..1574475	+	243	WP_008502222.1	hypothetical protein	-
CES92_RS07635	1574809..1575576	+	768	WP_008502221.1	conjugal transfer protein TraX	-
CES92_RS07640	1575598..1575831	-	234	WP_008502220.1	DUF2767 family protein	-
CES92_RS07645	1576680..1577693	-	1014	WP_059359379.1	replication initiation protein	-
CES92_RS07655	1578347..1578613	+	267	WP_007869691.1	DUF1778 domain-containing protein	Antitoxin
CES92_RS07660	1578601..1579086	+	486	WP_013087269.1	GNAT family N-acetyltransferase	Toxin
CES92_RS07665	1579293..1580638	+	1346	Protein_1483	ISNCY family transposase	-
CES92_RS07670	1580733..1580960	-	228	Protein_1484	transposase	-
CES92_RS07680	1581242..1581838	-	597	Protein_1485	IS3 family transposase	-
CES92_RS07690	1581903..1582304	+	402	Protein_1486	IS30 family transposase	-
CES92_RS07695	1582374..1583355	+	982	Protein_1487	IS5-like element ISKpn26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1571572..1595702	24130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17736.45 Da
• Isoelectric Point: 9.5181

>T78552 WP_013087269.1 NZ_CP022148:1578601-1579086 [Enterobacter roggenkampii]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Nucleotide

• Length: 486 bp

>T78552 NZ_CP022148:1578601-1579086 [Enterobacter roggenkampii]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10080.46 Da
• Isoelectric Point: 4.3837

>AT78552 WP_007869691.1 NZ_CP022148:1578347-1578613 [Enterobacter roggenkampii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT78552 NZ_CP022148:1578347-1578613 [Enterobacter roggenkampii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA