Detailed information of TA system TA078543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 40126..40661
• Replicon: plasmid unnamed2
• Accession: NZ_CP022141
• Organism: Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3W3C6
• Locus tag: LFZ47_RS25005
• Protein ID: WP_015062691.1
• Coordinates: 40374..40661 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3W3C5
• Locus tag: LFZ47_RS25000
• Protein ID: WP_015062690.1
• Coordinates: 40126..40377 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ47_RS24960	35134..35391	+	258	WP_134950290.1	hypothetical protein	-
LFZ47_RS24965	35430..37361	+	1932	WP_080224707.1	ParB/RepB/Spo0J family partition protein	-
LFZ47_RS25600	37552..38028	+	477	WP_141030773.1	hypothetical protein	-
LFZ47_RS24975	38249..38536	+	288	WP_080224709.1	hypothetical protein	-
LFZ47_RS24980	38572..38874	+	303	WP_080224710.1	type II toxin-antitoxin system HigB family toxin	-
LFZ47_RS24985	38880..39239	+	360	WP_080224711.1	helix-turn-helix domain-containing protein	-
LFZ47_RS24990	39268..39648	+	381	WP_080224712.1	hypothetical protein	-
LFZ47_RS25605	39750..40022	-	273	WP_157698318.1	hypothetical protein	-
LFZ47_RS25000	40126..40377	+	252	WP_015062690.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LFZ47_RS25005	40374..40661	+	288	WP_015062691.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LFZ47_RS25610	40667..41032	+	366	WP_139134637.1	hypothetical protein	-
LFZ47_RS25015	41029..41310	+	282	WP_080224713.1	hypothetical protein	-
LFZ47_RS25020	41495..42886	+	1392	WP_015062301.1	cysteine--tRNA ligase	-
LFZ47_RS25615	43411..43806	-	396	WP_015062300.1	hypothetical protein	-
LFZ47_RS25620	44041..44229	-	189	WP_015062299.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82715	82715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11043.06 Da
• Isoelectric Point: 10.5832

>T78543 WP_015062691.1 NZ_CP022141:40374-40661 [Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K]
MTYTVKFRDDALKEWLKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDAQLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T78543 NZ_CP022141:40374-40661 [Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K]
ATGACTTACACAGTCAAATTCAGGGATGATGCGTTGAAAGAGTGGCTGAAGCTGGATAAGGCCATTCAACAGCAGTTTGC
TAAAAAATTAAAGAAGTGCAGTGAAAATCCACATATTCCATCAGCAAAACTGCGAGGTATAAAGGATTGTTATAAAATTA
AACTTCGTGCGTCTGGCTTCCGACTGGTTTATCAGGTGATTGACGCTCAATTAATTATCGCTGTTGTAGCTGTAGGTAAA
CGTGAACGTAGTGACGTTTATAATCTTGCCAGCGAACGAATGAGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9212.44 Da
• Isoelectric Point: 4.0780

>AT78543 WP_015062690.1 NZ_CP022141:40126-40377 [Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQQLHDIDLD
SYL

Nucleotide

• Length: 252 bp

>AT78543 NZ_CP022141:40126-40377 [Salmonella enterica subsp. salamae serovar 55:k:z39 str. 1315K]
ATGCCTAACATAATTCTTACCGACACAAGCGCCAGCGTAAGCGAGCTAAAGAAAAATCCGATGGCTACAGTCAGCGCCGG
TGATGGATACCCGGTTGCTATTCTGAACCGCAACCAACCTGCCTTTTATTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCTTGGACGATCAGGAACTGGTTAAGCTGGTAGCCGAACGCAGCAACCAGCAACTGCACGATATAGATCTGGAT
AGCTACTTATGA

Structures

Toxin

• AlphaFold DB: I3W3C6

Antitoxin

• AlphaFold DB: I3W3C5