Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2172..2697 Replicon plasmid unnamed2
Accession NZ_CP022137
Organism Salmonella enterica subsp. diarizonae serovar 65:c:z str. SA20044251

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag LFZ55_RS24635 Protein ID WP_001159874.1
Coordinates 2172..2477 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag LFZ55_RS24640 Protein ID WP_000813642.1
Coordinates 2479..2697 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ55_RS24620 1..930 + 930 WP_088734789.1 Rpn family recombination-promoting nuclease/putative transposase -
LFZ55_RS24625 1081..1863 - 783 WP_088734791.1 site-specific integrase -
LFZ55_RS24635 2172..2477 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
LFZ55_RS24640 2479..2697 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LFZ55_RS24645 3442..3672 + 231 WP_088734793.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LFZ55_RS24650 3669..4085 + 417 WP_088734795.1 type II toxin-antitoxin system VapC family toxin -
LFZ55_RS24655 4132..5055 - 924 Protein_6 pcar -
LFZ55_RS24660 5051..5379 - 329 Protein_7 Tn3 family transposase -
LFZ55_RS24665 5450..6283 - 834 WP_080071163.1 SdiA-regulated domain-containing protein -
LFZ55_RS24670 6444..7097 - 654 WP_080071162.1 DsbA family protein -
LFZ55_RS24675 7355..7693 - 339 WP_080071161.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..66457 66457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T78538 WP_001159874.1 NZ_CP022137:c2477-2172 [Salmonella enterica subsp. diarizonae serovar 65:c:z str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T78538 NZ_CP022137:c2477-2172 [Salmonella enterica subsp. diarizonae serovar 65:c:z str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT78538 WP_000813642.1 NZ_CP022137:c2697-2479 [Salmonella enterica subsp. diarizonae serovar 65:c:z str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT78538 NZ_CP022137:c2697-2479 [Salmonella enterica subsp. diarizonae serovar 65:c:z str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References