Detailed information of TA system TA078537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2609851..2610356
• Replicon: chromosome
• Accession: NZ_CP022134
• Organism: Halomonas sp. HG01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: UN84_RS12460
• Protein ID: WP_046079907.1
• Coordinates: 2610102..2610356 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510ZHU8
• Locus tag: UN84_RS12455
• Protein ID: WP_035594107.1
• Coordinates: 2609851..2610105 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UN84_RS12445	2605212..2606477	+	1266	WP_046079908.1	exonuclease SbcCD subunit D C-terminal domain-containing protein	-
UN84_RS12450	2606474..2609776	+	3303	WP_173835006.1	AAA family ATPase	-
UN84_RS12455	2609851..2610105	+	255	WP_035594107.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
UN84_RS12460	2610102..2610356	+	255	WP_046079907.1	Txe/YoeB family addiction module toxin	Toxin
UN84_RS12465	2610388..2611248	+	861	WP_046079906.1	SDR family oxidoreductase	-
UN84_RS12470	2611310..2612419	-	1110	WP_046079905.1	Fic family protein	-
UN84_RS12475	2612606..2614297	-	1692	WP_046079904.1	SWIM zinc finger family protein	-
UN84_RS12480	2614708..2615274	+	567	WP_173835007.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10257.84 Da
• Isoelectric Point: 9.8548

>T78537 WP_046079907.1 NZ_CP022134:2610102-2610356 [Halomonas sp. HG01]
MKLTFSEHAWEEYLYWQKTDKKVLRRINQLIKEIQRTPFEGIGKPEPLKHGLAGYWSRRINDEHRLVYKVTEDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T78537 NZ_CP022134:2610102-2610356 [Halomonas sp. HG01]
ATGAAGCTCACCTTCTCCGAGCATGCCTGGGAGGAATACCTCTACTGGCAGAAGACCGACAAGAAGGTGCTACGCCGGAT
CAACCAGCTGATCAAGGAGATCCAGCGCACGCCCTTCGAGGGCATCGGCAAGCCGGAGCCCCTGAAGCATGGCCTCGCGG
GTTACTGGTCGCGACGCATCAACGATGAACATCGCCTCGTCTACAAGGTGACGGAAGATGCCTTGCTGATTGCTCAGCTG
CGTTATCACTACTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9521.79 Da
• Isoelectric Point: 4.5037

>AT78537 WP_035594107.1 NZ_CP022134:2609851-2610105 [Halomonas sp. HG01]
MEAISYTAARSHLAKTMQQVCDDHMPITITRSKAPSVVMISLEDYEALQETAYLLRSPKNARRLLESIAQLEEGDGQERE
LIEE

Nucleotide

• Length: 255 bp

>AT78537 NZ_CP022134:2609851-2610105 [Halomonas sp. HG01]
ATGGAAGCCATCAGCTATACGGCGGCGCGCAGTCACCTGGCGAAGACCATGCAGCAAGTGTGCGACGATCACATGCCCAT
CACCATCACCCGCAGCAAGGCGCCGTCGGTGGTGATGATATCGCTGGAAGACTACGAGGCTCTGCAGGAGACCGCCTACC
TGCTGCGCTCGCCGAAGAACGCCCGCCGCCTGCTCGAATCCATCGCCCAGTTGGAGGAAGGCGACGGGCAGGAGCGGGAG
CTCATCGAGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A510ZHU8