Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1719018..1720669 Replicon chromosome
Accession NZ_CP022134
Organism Halomonas sp. HG01

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag UN84_RS08115 Protein ID WP_046078726.1
Coordinates 1719018..1720364 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag UN84_RS08120 Protein ID WP_046078727.1
Coordinates 1720361..1720669 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UN84_RS08090 1714199..1714969 - 771 WP_046078722.1 TatD family hydrolase -
UN84_RS08095 1715132..1716721 - 1590 WP_035598590.1 peptide chain release factor 3 -
UN84_RS08100 1716914..1717219 - 306 WP_046078723.1 hypothetical protein -
UN84_RS08105 1717356..1718213 - 858 WP_046078724.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
UN84_RS08110 1718207..1718872 - 666 WP_046078725.1 SDR family oxidoreductase -
UN84_RS08115 1719018..1720364 + 1347 WP_046078726.1 type II toxin-antitoxin system HipA family toxin Toxin
UN84_RS08120 1720361..1720669 + 309 WP_046078727.1 helix-turn-helix domain-containing protein Antitoxin
UN84_RS08125 1720686..1723823 - 3138 WP_046078728.1 efflux RND transporter permease subunit -
UN84_RS08130 1723820..1725061 - 1242 WP_202020723.1 biotin/lipoyl-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50701.28 Da        Isoelectric Point: 6.1435

>T78536 WP_046078726.1 NZ_CP022134:1719018-1720364 [Halomonas sp. HG01]
MQLTIQIHHQTRWQNAALLEIPAPEQGTRGPARLGYFQDYALAWMFHDDEHACSLTLPVELMMTHRGDRWFGFLEDIMPA
GASRRYWIEHLGLQDLDPSQQDGELLRRGTIAPVGNLRIREALPERPAGYALASLRFPQEEVLERHTDFLEYAQQMGAAS
GGATGAGGEAPKLLVRRTPDRQVWIDTWQDDTTTPDAHCLVKFPRGSRSDDDCDILRAEYHYYRELHALGVDTVPVEGLE
LHEGTRYPSLWLPRFDVEWRQGQLHRHGLESVYALLGVAPGTHLRHPAAIRRLVALLKGQHRVREGREPFDAAAFVIEWV
KRDLLNLAFGNSDNHGRNAALLKRPEGIWHAPVYDFAPMKADPEGVTRTTQWGPTFERGGDVDWPAVAEHLADLVEPERL
MGELRALGDRLPGLRDRLADHGVPSRILDMPAVGLNHLDDRLTRWGLT

Download         Length: 1347 bp

>T78536 NZ_CP022134:1719018-1720364 [Halomonas sp. HG01]
ATGCAGCTGACGATCCAGATCCATCACCAGACACGTTGGCAGAACGCCGCGCTGCTCGAGATTCCTGCGCCGGAACAGGG
AACGCGTGGCCCCGCCAGGCTGGGATACTTCCAGGACTATGCACTGGCCTGGATGTTCCACGACGACGAACACGCGTGCA
GCCTGACCCTGCCCGTCGAATTGATGATGACCCACCGCGGCGATCGCTGGTTCGGCTTTCTCGAGGACATCATGCCGGCC
GGTGCCAGCCGCCGCTACTGGATCGAGCATCTGGGGTTGCAGGACCTCGACCCCAGCCAGCAGGACGGTGAACTGCTGCG
CCGCGGTACCATAGCGCCGGTAGGAAACCTGCGCATCCGCGAAGCACTCCCCGAACGCCCGGCCGGATATGCCCTGGCGT
CCCTGCGCTTCCCGCAGGAAGAGGTGCTGGAACGCCATACAGACTTCCTCGAATACGCTCAGCAGATGGGCGCCGCCAGC
GGCGGCGCCACCGGCGCCGGTGGGGAGGCCCCCAAGCTGCTGGTACGTCGCACCCCGGATCGTCAGGTGTGGATCGACAC
CTGGCAGGACGACACCACCACGCCCGACGCCCATTGTCTGGTCAAGTTTCCCCGCGGGAGCCGCAGCGACGACGACTGCG
ACATCCTGCGCGCCGAATATCACTACTATCGCGAGTTGCATGCCCTTGGCGTGGATACCGTGCCTGTCGAAGGCCTGGAG
CTCCACGAGGGCACCCGCTATCCCTCTCTCTGGCTGCCGCGTTTCGATGTCGAATGGCGCCAGGGCCAGCTCCATCGCCA
CGGTCTGGAATCGGTATACGCGCTGCTCGGCGTCGCACCGGGCACTCACCTGCGCCACCCCGCGGCCATTCGCCGACTGG
TGGCGCTGCTGAAGGGCCAGCATCGGGTACGCGAGGGCCGCGAGCCCTTCGATGCGGCCGCTTTCGTCATCGAATGGGTC
AAGCGGGACCTGCTCAATCTGGCCTTCGGCAATTCGGACAATCACGGTCGCAATGCCGCCCTGCTCAAGCGTCCCGAGGG
CATCTGGCACGCACCGGTCTATGACTTCGCCCCCATGAAGGCCGACCCCGAGGGCGTGACCCGGACGACGCAGTGGGGGC
CGACATTCGAACGAGGCGGAGACGTCGACTGGCCGGCAGTCGCCGAGCACCTGGCGGATCTGGTCGAGCCGGAGCGCCTG
ATGGGTGAGCTACGAGCCCTGGGCGACCGCCTGCCGGGCCTTCGCGATCGACTGGCGGATCACGGCGTGCCGTCGCGCAT
CCTGGACATGCCGGCGGTGGGACTGAACCATCTCGATGATCGCCTGACACGCTGGGGGCTGACATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11394.25 Da        Isoelectric Point: 10.7482

>AT78536 WP_046078727.1 NZ_CP022134:1720361-1720669 [Halomonas sp. HG01]
MKPQARSPQARQAALLEQLRLLMRGETTEGRVLRTLRREVLGLTQTAYAELVGVSRRTLSDIERDAGNASMASLDRVFRP
LGLKVGLMPRQPELLAELLDEP

Download         Length: 309 bp

>AT78536 NZ_CP022134:1720361-1720669 [Halomonas sp. HG01]
ATGAAGCCACAGGCCCGCTCTCCCCAGGCGCGCCAGGCGGCGCTGCTCGAACAGCTGCGCCTGCTGATGCGCGGCGAGAC
CACCGAAGGCCGCGTGCTGCGCACCCTTCGGCGCGAGGTCCTGGGCCTGACCCAGACGGCCTATGCCGAGCTGGTCGGCG
TCAGCCGGCGCACCCTGTCGGACATCGAGCGGGACGCCGGCAACGCCTCCATGGCCAGCCTCGACCGGGTCTTCCGACCG
CTGGGGCTCAAGGTCGGCCTGATGCCGCGACAGCCCGAACTGCTGGCCGAACTGCTCGACGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References