Detailed information of TA system TA078535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1618182..1619750
• Replicon: chromosome
• Accession: NZ_CP022134
• Organism: Halomonas sp. HG01

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A327I822
• Locus tag: UN84_RS07685
• Protein ID: WP_046078661.1
• Coordinates: 1618182..1619486 (-)
• Length: 435 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: UN84_RS07690
• Protein ID: WP_046078662.1
• Coordinates: 1619490..1619750 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UN84_RS07655	1614718..1615359	-	642	WP_035593279.1	pyridoxamine 5'-phosphate oxidase	-
UN84_RS07660	1615580..1615975	-	396	WP_046078656.1	DUF2069 domain-containing protein	-
UN84_RS07665	1615972..1616589	-	618	WP_046078657.1	NAD(P)H:quinone oxidoreductase	-
UN84_RS07670	1616621..1616962	-	342	WP_046078658.1	arsenate reductase (glutaredoxin)	-
UN84_RS07675	1617063..1617530	-	468	WP_046078659.1	MgtC/SapB family protein	-
UN84_RS07680	1617673..1618101	-	429	WP_046078660.1	gamma-glutamylcyclotransferase	-
UN84_RS07685	1618182..1619486	-	1305	WP_046078661.1	type II toxin-antitoxin system HipA family toxin	Toxin
UN84_RS07690	1619490..1619750	-	261	WP_046078662.1	helix-turn-helix domain-containing protein	Antitoxin
UN84_RS07695	1619908..1620498	+	591	WP_035593255.1	DNA endonuclease SmrA	-
UN84_RS07700	1620573..1621091	-	519	WP_046078663.1	DUF934 domain-containing protein	-
UN84_RS07705	1621084..1622736	-	1653	WP_046078664.1	nitrite/sulfite reductase	-
UN84_RS07710	1622877..1624205	-	1329	WP_046078665.1	MATE family efflux transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-396)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 435 a.a.
• Molecular weight: 48062.86 Da
• Isoelectric Point: 6.5937

>T78535 WP_046078661.1 NZ_CP022134:c1619486-1618182 [Halomonas sp. HG01]
MANLTVAMNGIEVGTLSLARSGAMAFQYRREWIERPGARAVSLSLPLSTAAYRGERVYNFFDNLLPDSEAIRARMQARFR
VPTRHPFDLLASIGRDCVGAIQLTPEDAPSGDVHGVTAEPLDDHAIEALLSGYQDAPLGMAEGQDFRISLAGAQEKTALL
WHQGRWQRPTGSTPTSHIFKLPIGFLEHSNIDLRQSNANEWLCLRLLEAFGLPAAKTALARFGDQEVLVVERFDRRWSRD
GSWLMRLPQEDFCQALGIAPALKYESDGGPGIAQAMRLLRGSQQAGVDRERFFKAQILFWLLAAIDGHAKNFSLFLEPGS
AYRMTPMYDVISAYPLMRQGSMAAERAKMAMALKGKNRHYRWSRMAPRHFIATAEQVDYSPERVTALMEEIAGSAERIVG
DLAADLPADFPAATSDPILEGVLQQASRLADFLA

Nucleotide

• Length: 1305 bp

>T78535 NZ_CP022134:c1619486-1618182 [Halomonas sp. HG01]
ATGGCGAATCTCACCGTCGCGATGAACGGCATCGAGGTCGGCACCCTGAGCCTGGCGCGCTCCGGCGCCATGGCCTTCCA
GTACCGTCGTGAATGGATCGAGCGCCCCGGCGCCCGGGCCGTCTCGCTCTCGCTGCCGCTCTCCACGGCGGCGTACCGCG
GCGAGCGAGTCTACAACTTCTTCGACAACCTGCTGCCGGACTCGGAGGCGATCCGCGCCCGCATGCAGGCCCGCTTCCGA
GTGCCGACGCGCCACCCCTTCGACCTGCTGGCGAGCATCGGCCGAGACTGCGTCGGCGCCATCCAGCTCACCCCCGAGGA
TGCCCCGAGTGGCGACGTCCACGGCGTCACCGCCGAGCCGCTCGATGATCACGCCATCGAGGCGCTGCTGTCCGGCTACC
AGGACGCTCCGCTGGGCATGGCCGAGGGCCAGGATTTTCGCATCTCGCTGGCCGGCGCCCAGGAAAAGACGGCGCTACTC
TGGCATCAGGGCCGCTGGCAGCGCCCCACCGGCAGCACACCCACCAGTCACATCTTCAAGCTGCCGATCGGCTTTCTCGA
ACACAGCAACATCGATCTGCGCCAGAGCAACGCCAACGAGTGGCTGTGCCTGCGCCTGCTGGAGGCCTTCGGCCTGCCGG
CGGCGAAGACCGCGCTCGCCCGCTTCGGCGACCAGGAGGTGCTGGTAGTCGAACGCTTCGACCGCCGCTGGTCGCGGGAC
GGGTCCTGGCTCATGCGCCTGCCCCAGGAAGACTTCTGCCAGGCGCTGGGAATTGCCCCGGCGCTCAAGTACGAGAGCGA
CGGCGGCCCGGGAATCGCCCAGGCCATGCGCCTGCTGCGCGGCTCCCAGCAGGCCGGCGTGGACCGGGAGCGCTTCTTCA
AGGCCCAGATCCTGTTCTGGCTGCTGGCCGCCATCGACGGGCATGCCAAGAACTTCAGCCTGTTCCTCGAGCCGGGAAGC
GCCTATCGAATGACGCCGATGTATGACGTCATCTCGGCCTACCCGCTCATGCGCCAGGGCAGCATGGCCGCCGAGCGCGC
CAAGATGGCCATGGCCCTGAAGGGCAAGAATCGCCACTACCGCTGGTCGCGGATGGCGCCCCGGCACTTCATCGCCACCG
CCGAGCAGGTCGATTATTCGCCCGAACGCGTCACCGCGCTGATGGAGGAGATCGCCGGCTCCGCCGAGCGGATCGTCGGT
GACCTCGCCGCCGACCTGCCCGCCGACTTCCCGGCGGCGACCAGCGACCCCATCCTCGAAGGCGTCCTCCAGCAGGCATC
GAGACTGGCGGACTTCCTGGCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9887.11 Da
• Isoelectric Point: 6.0792

>AT78535 WP_046078662.1 NZ_CP022134:c1619750-1619490 [Halomonas sp. HG01]
MKITSPEMLAHSLKNARKRRQLTQQATAEQIGIKQATVSGFEHHPERSRLETLFKLLSALELELHVTERDSTEESASPEA
CWDQEW

Nucleotide

• Length: 261 bp

>AT78535 NZ_CP022134:c1619750-1619490 [Halomonas sp. HG01]
ATGAAGATCACCTCACCCGAGATGCTCGCGCACTCGCTGAAGAACGCGCGCAAGCGCCGCCAGCTGACGCAGCAGGCCAC
CGCCGAGCAGATCGGCATCAAGCAGGCGACCGTCTCCGGCTTCGAGCACCACCCGGAGCGCAGCCGGCTCGAGACGCTGT
TCAAGCTGCTGTCGGCCCTCGAGCTGGAGCTTCACGTCACCGAACGCGACAGCACCGAGGAATCGGCAAGCCCCGAGGCG
TGCTGGGACCAGGAGTGGTAG

Structures

Toxin

• AlphaFold DB: A0A327I822