Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 336774..338341 Replicon chromosome
Accession NZ_CP022133
Organism Idiomarina piscisalsi strain 10PY1A

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CEW91_RS01595 Protein ID WP_088767382.1
Coordinates 336774..338084 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CEW91_RS01600 Protein ID WP_088767383.1
Coordinates 338084..338341 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEW91_RS01565 332343..333191 - 849 WP_088769327.1 phosphatidylserine decarboxylase -
CEW91_RS01570 333236..334279 - 1044 WP_088767379.1 small ribosomal subunit biogenesis GTPase RsgA -
CEW91_RS01575 334349..334900 + 552 WP_088767380.1 oligoribonuclease -
CEW91_RS01580 334940..336469 + 1530 WP_088767381.1 BCCT family transporter -
CEW91_RS01595 336774..338084 - 1311 WP_088767382.1 type II toxin-antitoxin system HipA family toxin Toxin
CEW91_RS01600 338084..338341 - 258 WP_088767383.1 helix-turn-helix domain-containing protein Antitoxin
CEW91_RS01605 338473..339618 - 1146 WP_088767384.1 dicarboxylate/amino acid:cation symporter -
CEW91_RS01610 339664..340581 - 918 WP_088767385.1 histone deacetylase family protein -
CEW91_RS01615 340585..342426 - 1842 WP_088767386.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49097.31 Da        Isoelectric Point: 8.5448

>T78531 WP_088767382.1 NZ_CP022133:c338084-336774 [Idiomarina piscisalsi]
MDKLDIYMNGLLVGELHRRHSGAHRFNYSINWLDTPGARPISLSMPLTRNAYEGAEVINFFDNLLPDSQEVRDRIVARYR
ADSKQPFDLLKAVGRDTVGALQFYPQGEQPGNIRTINYQPLNDSELEKVLLGYQSKAPLGMVNELNDFRISIAGAQEKTA
LLKIEDKWCIPEGTTPTSHIIKLPIGKIQGADHTIDLSDSVENELLCLEIAREFGFDVPACEIVNTGKVKALAVERFDRK
YSSDKSWLMRLPQEDYCQVLSCPSARKYESDGGPSIAQIMKHLQSSSNSHKDRRTFMAAQVLFFLLGATDGHAKNFSVFI
EPEGGFKLTPLYDILSAYPAVGGQGLHLRDLKLAMTLKGSKGRKSKLFQIYGRHFISSAKEAQYSLKEMQDILKLMHAST
DNVIERVSKRLPKDFPMKVSEPIFEGLSRRKERLIS

Download         Length: 1311 bp

>T78531 NZ_CP022133:c338084-336774 [Idiomarina piscisalsi]
ATGGATAAACTCGATATTTATATGAACGGGCTACTGGTCGGTGAGCTGCACCGTAGGCACTCTGGCGCCCACCGTTTTAA
CTACAGTATCAACTGGCTCGATACACCGGGCGCTCGCCCAATTTCGTTATCGATGCCTCTAACAAGAAACGCCTACGAAG
GTGCTGAAGTCATCAACTTTTTTGATAACCTCCTGCCCGATAGTCAGGAAGTTCGAGACAGGATTGTTGCGCGCTACCGA
GCCGACTCGAAACAACCTTTCGATCTTCTAAAAGCAGTAGGCCGAGATACAGTAGGCGCTTTACAGTTTTACCCTCAAGG
GGAACAACCTGGCAATATAAGGACAATAAACTACCAGCCTCTGAATGATAGCGAGCTAGAAAAGGTTCTTCTAGGCTATC
AGTCTAAGGCACCGCTTGGCATGGTGAATGAGCTCAATGACTTTCGTATATCGATAGCTGGAGCACAAGAGAAAACAGCG
TTACTTAAAATAGAAGATAAATGGTGTATTCCCGAAGGAACTACACCGACAAGCCACATCATCAAACTACCTATCGGAAA
GATCCAAGGAGCAGACCATACTATCGACTTATCCGACAGCGTTGAAAATGAGCTGCTGTGTCTGGAAATCGCCAGAGAAT
TCGGTTTCGACGTGCCCGCTTGTGAGATTGTTAACACAGGTAAGGTAAAAGCTCTGGCCGTAGAGCGCTTCGATCGCAAA
TATTCCAGTGATAAATCCTGGCTCATGCGCCTGCCGCAAGAGGATTACTGTCAGGTACTTAGCTGTCCTTCTGCTCGAAA
GTACGAGTCTGACGGCGGTCCGTCCATAGCGCAAATTATGAAGCACTTACAAAGCTCTTCTAACTCTCACAAAGACAGAA
GAACTTTTATGGCAGCACAGGTGCTATTTTTTCTGTTAGGAGCAACCGACGGGCACGCTAAAAACTTTTCTGTGTTTATA
GAGCCAGAAGGTGGTTTCAAATTAACTCCGCTTTACGACATTCTTTCGGCGTACCCAGCAGTCGGAGGTCAAGGGCTTCA
TTTAAGAGACTTAAAACTGGCGATGACACTTAAAGGCTCAAAAGGTCGAAAGTCAAAGCTTTTCCAGATTTACGGGCGTC
ATTTCATCAGTTCGGCAAAGGAAGCGCAGTACAGCCTAAAAGAGATGCAGGACATTCTTAAGCTAATGCATGCAAGCACA
GATAACGTTATTGAAAGGGTGAGTAAGCGCTTACCCAAAGACTTTCCGATGAAAGTTTCAGAGCCTATTTTTGAAGGTCT
TAGTCGTCGAAAAGAGAGGCTTATTAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9617.73 Da        Isoelectric Point: 5.6175

>AT78531 WP_088767383.1 NZ_CP022133:c338341-338084 [Idiomarina piscisalsi]
MKITSPHALAVHLKDERKQQRLSQANVAESVGLRQGTVSSFELSPEKSQIDTLFRLLSALGLELSIKSKEDAQENNTEHS
WNEEW

Download         Length: 258 bp

>AT78531 NZ_CP022133:c338341-338084 [Idiomarina piscisalsi]
ATGAAAATTACAAGCCCCCACGCGTTAGCGGTTCATTTAAAAGATGAAAGAAAACAACAAAGATTAAGTCAGGCAAACGT
TGCTGAATCCGTTGGTTTAAGACAGGGCACTGTCTCAAGCTTTGAGCTTTCTCCAGAGAAAAGCCAAATAGATACGTTAT
TTCGGCTTCTATCAGCGCTTGGGCTAGAGTTAAGTATTAAGAGCAAGGAAGACGCTCAGGAAAACAACACTGAACACTCA
TGGAATGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References