Detailed information of TA system TA078530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 304972..305590
• Replicon: chromosome
• Accession: NZ_CP022133
• Organism: Idiomarina piscisalsi strain 10PY1A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CEW91_RS01430
• Protein ID: WP_088767353.1
• Coordinates: 304972..305157 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CEW91_RS01435
• Protein ID: WP_088767354.1
• Coordinates: 305180..305590 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEW91_RS01410	300107..302980	-	2874	WP_088767350.1	insulinase family protein	-
CEW91_RS01415	303073..303945	-	873	WP_088767351.1	LysR family transcriptional regulator	-
CEW91_RS01420	304027..304650	-	624	WP_088767352.1	hypothetical protein	-
CEW91_RS01425	304691..304795	+	105	Protein_279	hypothetical protein	-
CEW91_RS01430	304972..305157	+	186	WP_088767353.1	type II toxin-antitoxin system HicA family toxin	Toxin
CEW91_RS01435	305180..305590	+	411	WP_088767354.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CEW91_RS01440	305725..307077	-	1353	WP_088767355.1	glutathione-disulfide reductase	-
CEW91_RS01445	307216..309516	-	2301	WP_088767356.1	S9 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-61)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7070.29 Da
• Isoelectric Point: 11.7279

>T78530 WP_088767353.1 NZ_CP022133:304972-305157 [Idiomarina piscisalsi]
VKQSAFRRWLEKQGVEVRQGTNHLKLYFQGKQSVMPRHPGKEIGEGLRSAIIKQLGLKKRQ

Nucleotide

• Length: 186 bp

>T78530 NZ_CP022133:304972-305157 [Idiomarina piscisalsi]
GTGAAGCAAAGTGCATTCAGACGCTGGCTTGAAAAGCAGGGTGTTGAGGTTAGGCAGGGAACGAACCATTTAAAGTTATA
CTTTCAGGGGAAGCAAAGCGTTATGCCGCGACATCCTGGAAAAGAAATTGGGGAAGGTCTACGAAGTGCAATTATCAAAC
AGCTGGGCCTAAAGAAAAGACAGTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15438.81 Da
• Isoelectric Point: 5.2231

>AT78530 WP_088767354.1 NZ_CP022133:305180-305590 [Idiomarina piscisalsi]
MNYPVIIKPDGNTFMVRFVDIPEAMTCADTYEEALEEARDALITAFEFYFEDQRQIPMPSDANGRDVISVPASVWAKVLL
LNTMLNEHISQAELARRMGTRKQEMQRIINLGHNTKIDKLNKALEAMGKHLSLSVV

Nucleotide

• Length: 411 bp

>AT78530 NZ_CP022133:305180-305590 [Idiomarina piscisalsi]
ATGAATTACCCTGTAATTATTAAGCCTGATGGCAACACGTTTATGGTTCGCTTTGTGGATATCCCAGAGGCAATGACTTG
TGCTGATACTTATGAAGAAGCCCTGGAAGAAGCGAGAGATGCTCTAATTACGGCGTTTGAGTTTTATTTTGAAGATCAGC
GTCAAATCCCTATGCCGTCAGACGCAAATGGACGGGATGTTATTAGTGTACCAGCAAGCGTTTGGGCTAAGGTGTTGCTG
CTAAACACGATGCTTAATGAACATATTAGTCAAGCTGAGTTAGCTCGGCGAATGGGCACTCGGAAACAAGAGATGCAACG
CATTATTAATCTTGGTCACAACACAAAAATCGATAAGCTAAACAAAGCGCTTGAGGCAATGGGTAAGCACTTGAGTTTGT
CTGTGGTTTAG