Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 4803763..4804315 Replicon chromosome
Accession NZ_CP022129
Organism Methylovulum psychrotolerans strain HV10_M2

Toxin (Protein)


Gene name parE Uniprot ID N9KMH0
Locus tag CEK71_RS21680 Protein ID WP_005166293.1
Coordinates 4804046..4804315 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID N9M459
Locus tag CEK71_RS21675 Protein ID WP_005166297.1
Coordinates 4803763..4804056 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEK71_RS21650 4799175..4800137 - 963 WP_088621319.1 biotin synthase BioB -
CEK71_RS21655 4800199..4800906 + 708 WP_088621320.1 ComF family protein -
CEK71_RS21660 4801081..4801728 + 648 WP_088621321.1 hypothetical protein -
CEK71_RS21665 4801805..4802917 - 1113 WP_088621322.1 tRNA guanosine(34) transglycosylase Tgt -
CEK71_RS21670 4803401..4803718 + 318 WP_157679557.1 hypothetical protein -
CEK71_RS21675 4803763..4804056 + 294 WP_005166297.1 hypothetical protein Antitoxin
CEK71_RS21680 4804046..4804315 + 270 WP_005166293.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CEK71_RS21685 4805693..4806004 + 312 WP_005166290.1 hypothetical protein -
CEK71_RS21690 4806028..4806297 - 270 WP_068550206.1 hypothetical protein -
CEK71_RS21700 4806588..4808444 + 1857 WP_198328380.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10736.18 Da        Isoelectric Point: 4.9047

>T78528 WP_005166293.1 NZ_CP022129:4804046-4804315 [Methylovulum psychrotolerans]
MKIEWTETARQDRRNIYDYLEERNPIAAIEIDDLIEEKTDLLVDNRLMGRTGRQKDTRELVIHPHYVVVYDITDIIRILR
VLHTSQEWS

Download         Length: 270 bp

>T78528 NZ_CP022129:4804046-4804315 [Methylovulum psychrotolerans]
ATGAAGATTGAGTGGACTGAAACAGCTCGCCAAGATCGTAGAAATATCTATGATTATCTTGAAGAACGCAACCCTATAGC
AGCTATTGAAATTGATGATTTAATTGAAGAAAAGACAGATTTACTTGTTGATAATCGACTGATGGGGCGCACAGGCAGAC
AGAAAGATACTAGGGAGTTAGTGATACATCCGCATTATGTGGTTGTATATGACATCACTGATATAATACGGATACTCAGA
GTGCTACACACATCGCAGGAGTGGTCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11060.48 Da        Isoelectric Point: 7.2044

>AT78528 WP_005166297.1 NZ_CP022129:4803763-4804056 [Methylovulum psychrotolerans]
MTEATFTFRVDHDLKQEFSSLAKTVDRSGAQLIRDFMRDFVKKQQEAADYDKWFKQQVQIGLNEANAGKLIPHEDVKAEF
AARRAATLAKLAAKNED

Download         Length: 294 bp

>AT78528 NZ_CP022129:4803763-4804056 [Methylovulum psychrotolerans]
ATGACAGAAGCGACTTTTACCTTTCGGGTAGACCATGACCTAAAGCAAGAATTTTCAAGCCTTGCTAAGACTGTTGATCG
GTCGGGGGCGCAGCTAATCCGTGACTTCATGCGTGACTTTGTTAAGAAGCAACAGGAAGCCGCAGACTATGACAAATGGT
TCAAGCAGCAGGTACAGATCGGCTTAAATGAAGCCAATGCAGGCAAGTTGATTCCACATGAGGACGTAAAGGCAGAGTTT
GCCGCTAGACGTGCTGCAACATTGGCGAAACTGGCAGCGAAGAATGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9KMH0

Antitoxin

Source ID Structure
AlphaFold DB N9M459

References