Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4506590..4507236 Replicon chromosome
Accession NZ_CP022129
Organism Methylovulum psychrotolerans strain HV10_M2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CEK71_RS20315 Protein ID WP_088621714.1
Coordinates 4506832..4507236 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CEK71_RS20310 Protein ID WP_088621713.1
Coordinates 4506590..4506832 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEK71_RS20295 4501755..4503122 - 1368 WP_088621082.1 TolC family protein -
CEK71_RS20300 4503972..4505642 + 1671 WP_088621083.1 DUF87 domain-containing protein -
CEK71_RS20305 4505901..4506521 + 621 WP_088621084.1 methylthioribulose 1-phosphate dehydratase -
CEK71_RS20310 4506590..4506832 + 243 WP_088621713.1 antitoxin Antitoxin
CEK71_RS20315 4506832..4507236 + 405 WP_088621714.1 type II toxin-antitoxin system VapC family toxin Toxin
CEK71_RS20320 4507378..4507938 + 561 WP_088621085.1 cupin -
CEK71_RS20325 4507935..4508624 + 690 WP_088621086.1 acireductone synthase -
CEK71_RS20330 4508632..4508856 - 225 WP_088621087.1 hypothetical protein -
CEK71_RS20335 4509499..4510008 + 510 WP_088621088.1 hypothetical protein -
CEK71_RS20340 4510024..4510317 + 294 WP_088621089.1 HPr-rel-A system PqqD family peptide chaperone -
CEK71_RS20345 4510390..4511235 + 846 WP_198328603.1 HprK-related kinase A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15112.59 Da        Isoelectric Point: 8.4550

>T78526 WP_088621714.1 NZ_CP022129:4506832-4507236 [Methylovulum psychrotolerans]
IRYLLDTNICIYLIKKHPPEVLARFQEIRLEQLYIPTVTVFELYYGIEKNNSQQRNLAALEHFIAPLTVMGFSLDAAKKA
AKIRSDLQKQGTPIGAYDIQIAAIACASDMTLLTNNTGEFARVKGLKLVNWVDN

Download         Length: 405 bp

>T78526 NZ_CP022129:4506832-4507236 [Methylovulum psychrotolerans]
ATCCGATACTTACTGGACACTAACATTTGTATTTATCTGATAAAAAAACATCCGCCAGAAGTATTGGCCAGATTCCAAGA
GATTCGGCTTGAGCAATTATATATCCCTACGGTCACTGTTTTTGAGCTGTATTACGGGATTGAAAAAAATAATTCCCAGC
AACGTAATCTAGCGGCTTTAGAGCATTTTATCGCCCCGTTGACGGTTATGGGCTTTAGTCTTGACGCGGCTAAAAAAGCG
GCCAAAATTCGTAGTGACCTGCAAAAACAAGGTACGCCGATTGGGGCTTATGATATACAGATTGCCGCTATTGCCTGCGC
ATCCGATATGACATTATTAACCAATAATACGGGCGAGTTCGCACGGGTTAAGGGCTTAAAATTGGTAAATTGGGTGGATA
ATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9220.34 Da        Isoelectric Point: 4.7558

>AT78526 WP_088621713.1 NZ_CP022129:4506590-4506832 [Methylovulum psychrotolerans]
MTTAKLFQNGRSQAVRLPKEFRLPGSLVKISRDGDKIILEPLENAWTQWFSSMTEFSDDFMTEGRQQPESAQERNWEGLG

Download         Length: 243 bp

>AT78526 NZ_CP022129:4506590-4506832 [Methylovulum psychrotolerans]
ATGACAACGGCAAAACTTTTCCAAAATGGCCGCTCGCAAGCGGTGCGCTTACCTAAAGAATTTAGGTTGCCGGGTTCGCT
GGTCAAAATTTCTAGGGACGGTGATAAAATCATTTTAGAGCCTTTGGAAAATGCGTGGACGCAATGGTTTTCAAGCATGA
CAGAATTTTCTGATGATTTTATGACCGAAGGCCGGCAGCAACCAGAATCAGCCCAAGAACGGAATTGGGAGGGGTTGGGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References