Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3704972..3705624 Replicon chromosome
Accession NZ_CP022129
Organism Methylovulum psychrotolerans strain HV10_M2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CEK71_RS16730 Protein ID WP_198328597.1
Coordinates 3704972..3705382 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CEK71_RS16735 Protein ID WP_088620446.1
Coordinates 3705382..3705624 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEK71_RS16710 3700011..3701939 + 1929 WP_088620442.1 ATP-dependent zinc metalloprotease FtsH -
CEK71_RS16715 3702308..3703063 + 756 WP_088620443.1 SEL1-like repeat protein -
CEK71_RS16720 3703138..3703434 - 297 WP_088620444.1 prevent-host-death protein -
CEK71_RS16725 3703568..3704818 + 1251 WP_088620445.1 dicarboxylate/amino acid:cation symporter -
CEK71_RS16730 3704972..3705382 - 411 WP_198328597.1 type II toxin-antitoxin system VapC family toxin Toxin
CEK71_RS16735 3705382..3705624 - 243 WP_088620446.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CEK71_RS16740 3705719..3706381 - 663 WP_088620447.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase -
CEK71_RS16745 3706378..3707130 - 753 WP_088620448.1 5'/3'-nucleotidase SurE -
CEK71_RS16750 3707205..3707726 + 522 WP_088620449.1 Smr/MutS family protein -
CEK71_RS16755 3707858..3708610 - 753 WP_088620450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14782.32 Da        Isoelectric Point: 6.4726

>T78525 WP_198328597.1 NZ_CP022129:c3705382-3704972 [Methylovulum psychrotolerans]
MRYMLDTNMASYIIKSHPPAIRNRLALLPMESITVSAVTQGELLYGLARKGHPASLAKLIREFLFCVETLPWDGQAATVY
GDLRASCVSVGITLGALDMMIAAHAIAANTLLVTHDKAFSLVPNGVLTIEDWLNEV

Download         Length: 411 bp

>T78525 NZ_CP022129:c3705382-3704972 [Methylovulum psychrotolerans]
ATGCGTTATATGCTGGATACCAATATGGCCAGTTATATTATCAAAAGCCATCCCCCGGCGATCCGTAACCGACTGGCGTT
GCTGCCGATGGAAAGCATTACCGTATCCGCAGTTACCCAAGGCGAACTGTTATACGGCTTAGCGCGTAAGGGGCATCCGG
CCTCGCTTGCAAAACTTATCCGCGAATTTCTTTTTTGTGTTGAAACATTGCCTTGGGACGGGCAAGCCGCCACCGTTTAT
GGCGATTTACGCGCCTCTTGCGTGTCGGTCGGCATTACACTTGGCGCGCTCGACATGATGATTGCCGCCCATGCAATAGC
CGCCAATACCCTACTTGTCACCCATGATAAAGCATTCAGCCTAGTCCCCAATGGGGTTTTGACTATCGAAGATTGGCTGA
ATGAGGTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9131.40 Da        Isoelectric Point: 5.0651

>AT78525 WP_088620446.1 NZ_CP022129:c3705624-3705382 [Methylovulum psychrotolerans]
MQSTAKLFITGRSQAVRLPKEFRFSGAEVFIRRDPLTGEVILSPKPASWAAFFELADRTNIPADFMADREDLPNQERDLF

Download         Length: 243 bp

>AT78525 NZ_CP022129:c3705624-3705382 [Methylovulum psychrotolerans]
ATGCAGTCGACTGCGAAGCTATTTATCACAGGCAGAAGCCAAGCAGTGAGGCTTCCGAAAGAATTCCGTTTTTCGGGGGC
GGAAGTGTTTATCCGTCGTGACCCCTTGACTGGCGAAGTCATACTGTCACCCAAACCTGCATCTTGGGCGGCGTTTTTCG
AGCTGGCCGACCGCACCAATATCCCCGCCGATTTCATGGCGGACCGCGAAGACCTGCCGAACCAAGAGAGGGATTTGTTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References