Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2265720..2266242 Replicon chromosome
Accession NZ_CP022129
Organism Methylovulum psychrotolerans strain HV10_M2

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag CEK71_RS10315 Protein ID WP_088619309.1
Coordinates 2265967..2266242 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CEK71_RS10310 Protein ID WP_088619308.1
Coordinates 2265720..2265974 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEK71_RS10290 2261286..2262032 + 747 WP_088619305.1 putative DNA-binding domain-containing protein -
CEK71_RS10295 2262096..2263109 - 1014 WP_088619306.1 quinone-dependent dihydroorotate dehydrogenase -
CEK71_RS10300 2263179..2264279 - 1101 WP_088619307.1 glycine oxidase ThiO -
CEK71_RS10305 2264687..2265580 + 894 WP_088621572.1 hypothetical protein -
CEK71_RS10310 2265720..2265974 + 255 WP_088619308.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CEK71_RS10315 2265967..2266242 + 276 WP_088619309.1 Txe/YoeB family addiction module toxin Toxin
CEK71_RS10320 2266265..2267224 + 960 WP_088619310.1 prolyl aminopeptidase -
CEK71_RS10325 2267221..2267796 + 576 WP_088619311.1 UbiX family flavin prenyltransferase -
CEK71_RS10330 2268220..2269677 - 1458 WP_088619312.1 M48 family metallopeptidase -
CEK71_RS10335 2269894..2270283 + 390 WP_088619313.1 sulfurtransferase complex subunit TusD -
CEK71_RS10340 2270285..2270641 + 357 WP_088619314.1 sulfurtransferase complex subunit TusC -
CEK71_RS10345 2270733..2271068 + 336 WP_088621573.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(11-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10904.45 Da        Isoelectric Point: 9.4636

>T78521 WP_088619309.1 NZ_CP022129:2265967-2266242 [Methylovulum psychrotolerans]
MNRPANHCLAWTDAAWQDYLYWQEQDRKILKRLNKLIADTQKKPFTGIGKPEPLRENLAGFWSRRIDETNRLVYVVNDSH
LTILACRYHYQ

Download         Length: 276 bp

>T78521 NZ_CP022129:2265967-2266242 [Methylovulum psychrotolerans]
ATGAATAGGCCGGCCAACCACTGTTTGGCGTGGACAGATGCGGCTTGGCAAGATTATTTATATTGGCAGGAACAGGACAG
AAAAATCCTAAAACGCCTCAACAAACTCATCGCCGATACGCAAAAAAAACCGTTTACCGGCATAGGCAAGCCGGAACCGC
TGCGCGAAAACTTAGCCGGCTTTTGGTCACGGCGCATTGATGAAACCAACCGCTTGGTCTATGTGGTTAATGATAGCCAC
TTGACTATTCTTGCCTGCCGCTATCATTATCAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9381.63 Da        Isoelectric Point: 4.5219

>AT78521 WP_088619308.1 NZ_CP022129:2265720-2265974 [Methylovulum psychrotolerans]
MRILSFTQARNNLKSVLDDVINDADCTVITRRDAADAVVMSLDYYTSLMETVHLLKSPANAAHLAKSIEQYQAGLLTERE
LPDE

Download         Length: 255 bp

>AT78521 NZ_CP022129:2265720-2265974 [Methylovulum psychrotolerans]
ATGCGTATCCTCTCGTTTACCCAAGCAAGAAATAATTTAAAGTCCGTGCTCGATGATGTCATCAACGATGCCGATTGTAC
AGTTATCACCCGCCGTGATGCCGCTGATGCTGTGGTGATGTCTTTGGATTACTACACGAGTTTGATGGAAACTGTCCACC
TGCTCAAATCCCCAGCCAATGCGGCTCATCTCGCCAAATCAATTGAGCAATATCAGGCCGGACTGCTAACCGAGCGTGAG
TTGCCGGATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References