Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3345281..3345938 Replicon chromosome
Accession NZ_CP022127
Organism Klebsiella pneumoniae strain DHQP1605752_NV

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CEV20_RS18675 Protein ID WP_002916310.1
Coordinates 3345528..3345938 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CEV20_RS18670 Protein ID WP_002916312.1
Coordinates 3345281..3345547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEV20_RS18645 3340437..3341870 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
CEV20_RS18650 3341989..3342717 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CEV20_RS18655 3342767..3343078 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CEV20_RS18660 3343242..3343901 + 660 WP_002916317.1 hemolysin III family protein -
CEV20_RS18665 3344052..3345035 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
CEV20_RS18670 3345281..3345547 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CEV20_RS18675 3345528..3345938 + 411 WP_002916310.1 protein YgfX Toxin
CEV20_RS18680 3345945..3346466 - 522 WP_004144730.1 flavodoxin FldB -
CEV20_RS18685 3346567..3347463 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CEV20_RS18690 3347486..3348199 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CEV20_RS18695 3348205..3349938 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T78511 WP_002916310.1 NZ_CP022127:3345528-3345938 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T78511 NZ_CP022127:3345528-3345938 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT78511 WP_002916312.1 NZ_CP022127:3345281-3345547 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT78511 NZ_CP022127:3345281-3345547 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References