Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3197543..3198222 Replicon chromosome
Accession NZ_CP022127
Organism Klebsiella pneumoniae strain DHQP1605752_NV

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag CEV20_RS17915 Protein ID WP_020324801.1
Coordinates 3197881..3198222 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag CEV20_RS17910 Protein ID WP_020324792.1
Coordinates 3197543..3197860 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEV20_RS17885 3192757..3195909 + 3153 WP_022631414.1 AIDA repeat-containing protein -
CEV20_RS17890 3196002..3196241 + 240 WP_020324820.1 DUF905 domain-containing protein -
CEV20_RS17895 3196344..3196802 + 459 WP_020324813.1 antirestriction protein -
CEV20_RS17900 3196818..3197294 + 477 WP_020324797.1 RadC family protein -
CEV20_RS17905 3197303..3197530 + 228 WP_020324796.1 DUF987 domain-containing protein -
CEV20_RS17910 3197543..3197860 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CEV20_RS17915 3197881..3198222 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
CEV20_RS17920 3198338..3199171 + 834 WP_020324805.1 DUF4942 domain-containing protein -
CEV20_RS17930 3199474..3199980 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
CEV20_RS17935 3200080..3201921 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T78510 WP_020324801.1 NZ_CP022127:3197881-3198222 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T78510 NZ_CP022127:3197881-3198222 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT78510 WP_020324792.1 NZ_CP022127:3197543-3197860 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT78510 NZ_CP022127:3197543-3197860 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References