Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1438588..1439102 Replicon chromosome
Accession NZ_CP022123
Organism Fusobacterium nucleatum subsp. polymorphum strain KCOM 1275

Toxin (Protein)


Gene name relB Uniprot ID X7SD51
Locus tag CBG61_RS06870 Protein ID WP_005919455.1
Coordinates 1438588..1438845 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag CBG61_RS06875 Protein ID WP_005919458.1
Coordinates 1438845..1439102 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBG61_RS06850 1434482..1435789 - 1308 WP_005894570.1 electron transport complex subunit RsxC -
CBG61_RS06855 1435864..1436439 - 576 WP_032887401.1 aminoacyl-tRNA hydrolase -
CBG61_RS06860 1436649..1437386 - 738 WP_032887398.1 tRNA pseudouridine(38-40) synthase TruA -
CBG61_RS06865 1437395..1438471 - 1077 WP_032887394.1 DHH family phosphoesterase -
CBG61_RS06870 1438588..1438845 - 258 WP_005919455.1 Txe/YoeB family addiction module toxin Toxin
CBG61_RS06875 1438845..1439102 - 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CBG61_RS06880 1439229..1440296 - 1068 WP_005901428.1 glycerophosphodiester phosphodiesterase -
CBG61_RS06885 1440340..1441338 - 999 WP_088765103.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
CBG61_RS06890 1441364..1441837 - 474 WP_005894577.1 OmpH family outer membrane protein -
CBG61_RS06895 1441877..1443970 - 2094 WP_147368654.1 outer membrane protein assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10159.71 Da        Isoelectric Point: 9.7287

>T78499 WP_005919455.1 NZ_CP022123:c1438845-1438588 [Fusobacterium nucleatum subsp. polymorphum]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T78499 NZ_CP022123:c1438845-1438588 [Fusobacterium nucleatum subsp. polymorphum]
ATGTTATTAACTTGGACCGATTTTGCATGGAAACAATATGAAGAGCTACAAGAGAAGGATAAAAGGCTTATAAAGAAGAT
AAATATACTTATTAAGGATATAAAAAGAAATGGAAATGAAGGAATAGGTAAACCAGAGCCTTTACAACATGAGTTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTCTATAAAGTATCAGATAATCAAATAACAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT78499 WP_005919458.1 NZ_CP022123:c1439102-1438845 [Fusobacterium nucleatum subsp. polymorphum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT78499 NZ_CP022123:c1439102-1438845 [Fusobacterium nucleatum subsp. polymorphum]
ATGATAGCAACTAATTATTCTGAAGTTAGAAATAATTTAAAAGCTTATTGTGATAAGGCAACTAAGGACTATGAAACTAT
TATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATACAATAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAAGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2ZLL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References