Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3254115..3254735 Replicon chromosome
Accession NZ_CP022120
Organism Salmonella bongori serovar 66:z41:- str. SA19983605

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LFZ56_RS16195 Protein ID WP_001280991.1
Coordinates 3254517..3254735 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LFZ56_RS16190 Protein ID WP_000344807.1
Coordinates 3254115..3254489 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ56_RS16180 3249254..3250447 + 1194 WP_001039205.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LFZ56_RS16185 3250470..3253619 + 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
LFZ56_RS16190 3254115..3254489 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LFZ56_RS16195 3254517..3254735 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
LFZ56_RS16200 3254914..3255465 + 552 WP_001278796.1 maltose O-acetyltransferase -
LFZ56_RS16205 3255583..3256053 + 471 WP_000136180.1 YlaC family protein -
LFZ56_RS16210 3256106..3256246 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LFZ56_RS16215 3256252..3256512 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
LFZ56_RS16220 3256717..3258267 + 1551 WP_000213124.1 EAL domain-containing protein -
LFZ56_RS16230 3258506..3258895 + 390 WP_000908589.1 MGMT family protein -
LFZ56_RS16235 3258928..3259497 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T78494 WP_001280991.1 NZ_CP022120:3254517-3254735 [Salmonella bongori serovar 66:z41:- str. SA19983605]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T78494 NZ_CP022120:3254517-3254735 [Salmonella bongori serovar 66:z41:- str. SA19983605]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGATAACGAGTTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATTCCTTCTTCTGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT78494 WP_000344807.1 NZ_CP022120:3254115-3254489 [Salmonella bongori serovar 66:z41:- str. SA19983605]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT78494 NZ_CP022120:3254115-3254489 [Salmonella bongori serovar 66:z41:- str. SA19983605]
ATGGACGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
GAACCTTGAAGAAAGCAACCATGGTTGGGTTAACGATCCGACCTCAGCAGTCAATCTTCAGCTCAATGAACTGATCGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCACAGATAGATGAATACTTG
GACGACACCTTTATGTTGTTCAGTAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTTGTTAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References