Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2226980..2227722 Replicon chromosome
Accession NZ_CP022120
Organism Salmonella bongori serovar 66:z41:- str. SA19983605

Toxin (Protein)


Gene name tacT Uniprot ID A0A248K916
Locus tag LFZ56_RS11035 Protein ID WP_000521216.1
Coordinates 2227234..2227722 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID S5MPV7
Locus tag LFZ56_RS11030 Protein ID WP_020844238.1
Coordinates 2226980..2227246 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ56_RS11020 2222219..2224747 + 2529 WP_000613169.1 malto-oligosyltrehalose synthase -
LFZ56_RS11025 2224790..2226865 + 2076 WP_000210608.1 glycogen debranching protein GlgX -
LFZ56_RS11030 2226980..2227246 + 267 WP_020844238.1 DUF1778 domain-containing protein Antitoxin
LFZ56_RS11035 2227234..2227722 + 489 WP_000521216.1 GNAT family N-acetyltransferase Toxin
LFZ56_RS11040 2228280..2228669 + 390 WP_015702869.1 RidA family protein -
LFZ56_RS11045 2228737..2229816 - 1080 WP_000954703.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LFZ56_RS11050 2229993..2230481 - 489 WP_001293644.1 MarR family winged helix-turn-helix transcriptional regulator -
LFZ56_RS11055 2230526..2232034 + 1509 WP_000196705.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-151)

Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17719.47 Da        Isoelectric Point: 9.5852

>T78493 WP_000521216.1 NZ_CP022120:2227234-2227722 [Salmonella bongori serovar 66:z41:- str. SA19983605]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGGLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Download         Length: 489 bp

>T78493 NZ_CP022120:2227234-2227722 [Salmonella bongori serovar 66:z41:- str. SA19983605]
GTGGGAAAAGTAACCGCGCCTGCACCGTTATCCACGCTGCATAACCTGGCGGAATTCTGCTGCGGTGAAAGTCTGTTAGA
CGACTGGCTGCGGCAACGTGCGTTAAAAAACCAGGCGACTGGCGCATCCAGAACTTTTGTGGTGTGCAAAGCCGCCAGCC
ATCAGGTCGTTGGGTTTTATTCGCTGGCAACGGGCAGCGTTAATCACGCTGAAGCGACGGGCGGTTTGCGCCGCAATATG
CCCGATCCAATTCCGGTCATTATCCTGGCGCGTCTGGCTGTAGATGTGTCTTATCATGGAATCGGGCTGGGCGCGGATTT
ATTGCGCGATGCCATATTACGCGCGTATCGGGTGGCGGAAAATATCGGCGTTCGGGCGATGGTGGTGCAAGCGTTAACAG
AACAGGCTAAACGCTTCTATCTGCATCATGGTTTTCGGGAATCAGGTAAGCAAGAGAGGACGCTATTTCTTATCCTTCCG
GAAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9999.47 Da        Isoelectric Point: 4.7961

>AT78493 WP_020844238.1 NZ_CP022120:2226980-2227246 [Salmonella bongori serovar 66:z41:- str. SA19983605]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Download         Length: 267 bp

>AT78493 NZ_CP022120:2226980-2227246 [Salmonella bongori serovar 66:z41:- str. SA19983605]
ATGAAATCAGGCGTTCAACTCAATATTCGGGCCAAAGAGTCACAGCGGGCGTTAATCGATACGGCGGCCGAGATTCTGCA
TAAATCACGAACCGACTTTATCCTTGAAATGGCTTGCCAGGCAGCCGAAAACGTTATTCTGGATCGCCGGGTATTTAACC
TTAACGACGATCAATACGCCGAGTTTGTTGAAATGCTTGATGCGCCTGTTGCTACAAATCCGGCGCTGGATAACTTACTG
GCGAGAAAACCACTGTGGGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248K916

Antitoxin

Source ID Structure
AlphaFold DB S5MPV7

References