Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827825..828485 Replicon chromosome
Accession NZ_CP022120
Organism Salmonella bongori serovar 66:z41:- str. SA19983605

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag LFZ56_RS04235 Protein ID WP_000244759.1
Coordinates 828072..828485 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LFZ56_RS04230 Protein ID WP_000351186.1
Coordinates 827825..828091 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ56_RS04205 823822..825255 - 1434 WP_000737109.1 6-phospho-beta-glucosidase -
LFZ56_RS04210 825413..825724 + 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
LFZ56_RS04215 825888..826547 + 660 WP_024135108.1 hemolysin III family protein -
LFZ56_RS04220 826598..827578 - 981 WP_000896119.1 tRNA-modifying protein YgfZ -
LFZ56_RS04230 827825..828091 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LFZ56_RS04235 828072..828485 + 414 WP_000244759.1 protein YgfX Toxin
LFZ56_RS04240 828537..829058 - 522 WP_001055887.1 flavodoxin FldB -
LFZ56_RS04245 829171..830067 + 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
LFZ56_RS04250 830091..830804 + 714 WP_000745612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LFZ56_RS04255 830810..832543 + 1734 WP_000813377.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T78484 WP_000244759.1 NZ_CP022120:828072-828485 [Salmonella bongori serovar 66:z41:- str. SA19983605]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T78484 NZ_CP022120:828072-828485 [Salmonella bongori serovar 66:z41:- str. SA19983605]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTAATTTTATTGATGCCCTGGCCGTTGAGTTATACCCCATTGTGGATGATGCTACTGTCGCTGGTGGTGTTTGACTGCG
TTCGTAGTCAGCGCCGGATTAATACCTGTCAGGGAGAGATCAAGCTGCTAATGGATGGGCGCTTACGCTGGCAGGGGGAA
GACTGGGTGCTCCTGCGCCCGCCCTGGTTACTGAACAGCGGGATGGTGTTGCGTTTACGCGCCGAGTCCGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAGGCGGAATGGCGTGAGTTACGCCGTGTCATGTTGCAACAACCACTAT
CGGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT78484 WP_000351186.1 NZ_CP022120:827825-828091 [Salmonella bongori serovar 66:z41:- str. SA19983605]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT78484 NZ_CP022120:827825-828091 [Salmonella bongori serovar 66:z41:- str. SA19983605]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGCGACGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAGCTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References