Detailed information of TA system TA078483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 366976..367619
• Replicon: plasmid unnamed1
• Accession: NZ_CP022118
• Organism: Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: LFZ25_RS26310
• Protein ID: WP_088731675.1
• Coordinates: 366976..367392 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: LFZ25_RS26315
• Protein ID: WP_088731677.1
• Coordinates: 367389..367619 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ25_RS26275	362366..363130	+	765	WP_088731663.1	fimbrial protein	-
LFZ25_RS26285	363398..364111	+	714	WP_088731667.1	fimbrial protein	-
LFZ25_RS26290	364240..364830	+	591	WP_088731669.1	hypothetical protein	-
LFZ25_RS26295	364896..365108	+	213	WP_023994139.1	PefI	-
LFZ25_RS27325	365275..365532	+	258	WP_198387424.1	hypothetical protein	-
LFZ25_RS26300	365558..366406	+	849	WP_088731671.1	SdiA-regulated domain-containing protein	-
LFZ25_RS26310	366976..367392	-	417	WP_088731675.1	type II toxin-antitoxin system VapC family toxin	Toxin
LFZ25_RS26315	367389..367619	-	231	WP_088731677.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LFZ25_RS26325	368251..369180	+	930	WP_088731681.1	hypothetical protein	-
LFZ25_RS26330	369305..370093	+	789	WP_088731683.1	site-specific integrase	-
LFZ25_RS27195	370332..370499	-	168	WP_157719632.1	hypothetical protein	-
LFZ25_RS26345	370888..371280	+	393	WP_088731687.1	hypothetical protein	-
LFZ25_RS26350	371280..371891	+	612	WP_088731689.1	DUF2913 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..416444	416444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-44)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 20475.56 Da
• Isoelectric Point: 5.5500

>T78483 WP_088731675.1 NZ_CP022118:c367392-366976 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 417 bp

>T78483 NZ_CP022118:c367392-366976 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT78483 WP_088731677.1 NZ_CP022118:c367619-367389 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT78483 NZ_CP022118:c367619-367389 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
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