Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 347599..348356 Replicon plasmid unnamed1
Accession NZ_CP022118
Organism Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643

Toxin (Protein)


Gene name tacT Uniprot ID A0A241PXX4
Locus tag LFZ25_RS26170 Protein ID WP_023994162.1
Coordinates 347874..348356 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag LFZ25_RS26165 Protein ID WP_001195098.1
Coordinates 347599..347883 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFZ25_RS26120 343415..343582 - 168 WP_023994170.1 IS66 family insertion sequence element accessory protein TnpB -
LFZ25_RS26125 343569..343898 - 330 WP_023994169.1 IS66 family insertion sequence hypothetical protein -
LFZ25_RS26130 344031..344876 + 846 Protein_292 site-specific tyrosine recombinase XerC -
LFZ25_RS26135 344845..345132 + 288 WP_031619580.1 damage-inducible protein J -
LFZ25_RS26140 345129..345434 + 306 WP_088731641.1 type II toxin-antitoxin system RelE/ParE family toxin -
LFZ25_RS26145 346023..346449 + 427 Protein_295 DUF977 family protein -
LFZ25_RS26150 346475..346810 + 336 WP_088731643.1 hypothetical protein -
LFZ25_RS26155 347032..347259 - 228 WP_088731819.1 PIN domain-containing protein -
LFZ25_RS26160 347354..347443 + 90 WP_071790431.1 helix-turn-helix domain-containing protein -
LFZ25_RS26165 347599..347883 + 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
LFZ25_RS26170 347874..348356 + 483 WP_023994162.1 GNAT family N-acetyltransferase Toxin
LFZ25_RS26175 348671..349099 + 429 Protein_301 transposase -
LFZ25_RS26180 349416..349625 + 210 WP_023994160.1 hemolysin expression modulator Hha -
LFZ25_RS26185 349699..350051 - 353 Protein_303 transposase -
LFZ25_RS26190 350278..351251 + 974 Protein_304 IS256 family transposase -
LFZ25_RS26195 351253..351495 + 243 WP_088731645.1 hypothetical protein -
LFZ25_RS26200 351566..352498 + 933 WP_088731647.1 Rpn family recombination-promoting nuclease/putative transposase -
LFZ25_RS26205 352556..352768 + 213 WP_088731649.1 hypothetical protein -
LFZ25_RS26210 352810..353061 - 252 WP_023994153.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..416444 416444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 20654.05 Da        Isoelectric Point: 13.0041

>T78482 WP_023994162.1 NZ_CP022118:347874-348356 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Download         Length: 483 bp

>T78482 NZ_CP022118:347874-348356 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 12194.55 Da        Isoelectric Point: 12.7731

>AT78482 WP_001195098.1 NZ_CP022118:347599-347883 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKK

Download         Length: 285 bp

>AT78482 NZ_CP022118:347599-347883 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXX4

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References