Detailed information of TA system TA078481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 331918..332508
• Replicon: plasmid unnamed1
• Accession: NZ_CP022118
• Organism: Salmonella enterica subsp. enterica serovar Macclesfield str. S-1643

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A241PXU0
• Locus tag: LFZ25_RS26075
• Protein ID: WP_023994178.1
• Coordinates: 332176..332508 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: LFZ25_RS26070
• Protein ID: WP_088731816.1
• Coordinates: 331918..332175 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LFZ25_RS26060	327414..331308	-	3895	Protein_280	hypothetical protein	-
LFZ25_RS26070	331918..332175	+	258	WP_088731816.1	antitoxin	Antitoxin
LFZ25_RS26075	332176..332508	+	333	WP_023994178.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LFZ25_RS26085	333108..333713	+	606	Protein_283	transposase	-
LFZ25_RS26090	333781..335294	+	1514	WP_088730052.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..416444	416444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 14245.34 Da
• Isoelectric Point: 12.8414

>T78481 WP_023994178.1 NZ_CP022118:332176-332508 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 333 bp

>T78481 NZ_CP022118:332176-332508 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 11040.99 Da
• Isoelectric Point: 12.7294

>AT78481 WP_088731816.1 NZ_CP022118:331918-332175 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKK

Nucleotide

• Length: 258 bp

>AT78481 NZ_CP022118:331918-332175 [Salmonella enterica subsp. enterica serovar Macclesfield str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A241PXU0