Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1244271..1244926 Replicon chromosome
Accession NZ_CP022111
Organism Nitrospirillum amazonense CBAmc

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Y958_RS18720 Protein ID WP_088873465.1
Coordinates 1244271..1244669 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Y958_RS18725 Protein ID WP_088873466.1
Coordinates 1244666..1244926 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y958_RS18700 1239837..1240754 - 918 WP_211098613.1 LysR family transcriptional regulator -
Y958_RS18705 1240818..1241810 + 993 WP_088873462.1 zinc-dependent alcohol dehydrogenase family protein -
Y958_RS18710 1241845..1243509 - 1665 WP_088873463.1 sulfurtransferase -
Y958_RS18715 1243509..1244132 - 624 WP_088873464.1 cysteine dioxygenase -
Y958_RS18720 1244271..1244669 - 399 WP_088873465.1 type II toxin-antitoxin system VapC family toxin Toxin
Y958_RS18725 1244666..1244926 - 261 WP_088873466.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Y958_RS18730 1244994..1247228 - 2235 WP_088873467.1 TonB-dependent receptor -
Y958_RS18735 1247420..1247806 - 387 WP_088873468.1 hypothetical protein -
Y958_RS18740 1247924..1248811 - 888 WP_088873469.1 sigma-70 family RNA polymerase sigma factor -
Y958_RS18745 1248811..1249290 - 480 WP_211098614.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14523.89 Da        Isoelectric Point: 10.5493

>T78472 WP_088873465.1 NZ_CP022111:c1244669-1244271 [Nitrospirillum amazonense CBAmc]
MTRYLLDTNTVSHLVRRHPGVSQRVTTMPMSALAVSAITEGELLFGLARRPEAVRLSAAVRELLLRVDVLPWDSRVAEVY
GALRSHMAGSGRSLAPLDMLIAAHARAVDAVLVTNDRAFRQVPNLAIEDWVK

Download         Length: 399 bp

>T78472 NZ_CP022111:c1244669-1244271 [Nitrospirillum amazonense CBAmc]
ATGACCCGTTATCTGTTGGACACCAATACGGTTAGCCATCTGGTTCGCCGCCACCCTGGCGTATCGCAGCGTGTCACGAC
CATGCCCATGTCGGCTTTGGCCGTCTCCGCCATCACGGAGGGTGAGCTGTTGTTCGGTCTTGCCCGCCGACCCGAGGCTG
TGCGCCTTAGCGCGGCGGTCCGGGAGTTGCTGTTAAGGGTGGATGTCTTGCCCTGGGATAGCCGTGTGGCGGAAGTCTAT
GGTGCCTTACGGTCGCACATGGCTGGATCTGGCCGATCACTGGCCCCGTTGGACATGCTCATTGCCGCCCACGCGCGGGC
GGTTGATGCAGTGCTGGTGACAAACGATCGGGCTTTCCGACAGGTTCCGAACTTGGCGATTGAAGACTGGGTAAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9733.77 Da        Isoelectric Point: 4.3952

>AT78472 WP_088873466.1 NZ_CP022111:c1244926-1244666 [Nitrospirillum amazonense CBAmc]
MSDVAKLFINGRSQAVRLPAAYRFDAKEVYIRKDPETGDVILSRKPTDWSGFFAALEGVDVPADFLSQEERDQGSHERDP
FAGWEE

Download         Length: 261 bp

>AT78472 NZ_CP022111:c1244926-1244666 [Nitrospirillum amazonense CBAmc]
ATGAGTGATGTCGCCAAGCTTTTCATCAACGGCCGCAGCCAAGCGGTGCGCCTGCCGGCGGCCTATCGTTTCGACGCCAA
GGAAGTTTACATCCGCAAGGATCCGGAAACAGGAGACGTCATCCTTTCCCGTAAGCCGACGGACTGGTCGGGCTTCTTCG
CTGCCCTTGAGGGAGTGGATGTTCCCGCGGATTTCCTGAGCCAGGAGGAGCGGGACCAGGGTTCCCACGAGCGTGATCCG
TTCGCCGGATGGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References