Detailed information of TA system TA078469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2734635..2735665
• Replicon: chromosome
• Accession: NZ_CP022110
• Organism: Nitrospirillum amazonense CBAmc

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: Y958_RS12595
• Protein ID: WP_088872247.1
• Coordinates: 2734635..2735204 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: Y958_RS12600
• Protein ID: WP_088872639.1
• Coordinates: 2735201..2735665 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y958_RS12565	2730968..2731642	-	675	WP_088872244.1	(d)CMP kinase	-
Y958_RS12570	2731743..2733077	-	1335	WP_088872245.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
Y958_RS12580	2733342..2733746	+	405	WP_040843019.1	TIGR02300 family protein	-
Y958_RS31975	2734464..2734625	+	162	WP_186291182.1	hypothetical protein	-
Y958_RS12595	2734635..2735204	-	570	WP_088872247.1	PIN domain-containing protein	Toxin
Y958_RS12600	2735201..2735665	-	465	WP_088872639.1	excisionase family DNA-binding protein	Antitoxin
Y958_RS31395	2736425..2736760	+	336	WP_145727603.1	hypothetical protein	-
Y958_RS12605	2736770..2737861	+	1092	WP_088872248.1	XRE family transcriptional regulator	-
Y958_RS12610	2737865..2738302	-	438	WP_088872249.1	hypothetical protein	-
Y958_RS12615	2738373..2738819	-	447	WP_088872250.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-113)

Antitoxin

• Helix-turn-helix domain, group 17 (81-128)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21073.21 Da
• Isoelectric Point: 6.3764

>T78469 WP_088872247.1 NZ_CP022110:c2735204-2734635 [Nitrospirillum amazonense CBAmc]
VTVYTALLDANVLYPAPMRDLLMQLAVMDVFHAKWSADIHREWIEALMRTQPHRDRAKLEHTRDQMDRHTRDGLVTGYQG
LIASLTLPDPDDRHVLAAAIKGRCDAIVTQNLADFPEAALAPYGIEALHPDDFLLNQMSLDPAAFCTAVAKVRARLKNPP
YSVENYLATLTRQGLVATAGELRQYAALL

Nucleotide

• Length: 570 bp

>T78469 NZ_CP022110:c2735204-2734635 [Nitrospirillum amazonense CBAmc]
GTGACGGTGTACACGGCGCTTCTTGACGCCAATGTCCTGTATCCCGCGCCCATGCGGGACCTGCTGATGCAGCTCGCGGT
GATGGACGTCTTCCATGCCAAATGGAGCGCCGACATCCACCGCGAATGGATCGAGGCGCTGATGCGCACCCAACCCCACC
GCGACCGCGCCAAGCTGGAGCACACGCGCGACCAGATGGACCGGCATACCCGGGACGGCCTGGTGACCGGCTATCAGGGC
CTGATCGCGTCGCTGACCCTTCCCGACCCCGATGACCGGCATGTGCTGGCCGCCGCCATCAAGGGGCGCTGCGACGCCAT
CGTGACGCAGAACCTGGCGGACTTCCCCGAGGCGGCCCTGGCCCCCTATGGCATAGAGGCCCTGCACCCCGACGATTTCC
TTCTCAACCAGATGAGCTTGGACCCCGCCGCTTTCTGCACGGCCGTCGCCAAGGTCCGCGCCCGCCTCAAGAATCCGCCC
TACAGCGTTGAGAACTATCTGGCCACCTTGACCCGCCAAGGGCTGGTGGCCACCGCAGGTGAGCTACGGCAGTACGCCGC
CTTGCTGTAG

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16990.58 Da
• Isoelectric Point: 7.2066

>AT78469 WP_088872639.1 NZ_CP022110:c2735665-2735201 [Nitrospirillum amazonense CBAmc]
MTALAHRQPPPTEQEAALARRSGQNLSRFVAKGRPLTLRVKDAEQEQPIELPAGAVRMLMDILEAMAAGRGVTIIPENAE
LTTVQAADTLNVSRPFLIGLLEGKAIPYRMVGKHRRIRMEDVMAYKARIDADRERVLDQLVADAQENDMGYGAS

Nucleotide

• Length: 465 bp

>AT78469 NZ_CP022110:c2735665-2735201 [Nitrospirillum amazonense CBAmc]
ATGACCGCGCTTGCCCACCGCCAACCACCACCCACCGAGCAAGAGGCGGCGCTTGCCCGCCGCTCGGGCCAGAACCTGTC
GCGCTTCGTTGCCAAGGGCCGGCCCCTGACGCTGCGGGTGAAGGACGCTGAACAGGAACAGCCCATCGAATTGCCCGCCG
GCGCCGTGCGGATGCTGATGGACATCCTGGAGGCGATGGCGGCCGGACGCGGCGTGACCATCATCCCGGAGAATGCGGAA
CTGACGACGGTGCAGGCGGCCGACACCCTCAACGTCTCCCGCCCCTTCCTCATCGGCTTGCTGGAGGGCAAGGCCATCCC
CTATCGCATGGTGGGGAAGCATCGCCGCATCCGCATGGAAGACGTCATGGCCTATAAGGCCCGCATTGATGCGGATCGGG
AGCGGGTGCTGGACCAGTTGGTCGCGGACGCCCAGGAGAACGACATGGGTTATGGTGCGTCGTGA