Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2661362..2661936 Replicon chromosome
Accession NZ_CP022110
Organism Nitrospirillum amazonense CBAmc

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Y958_RS12220 Protein ID WP_088872195.1
Coordinates 2661604..2661936 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Y958_RS12215 Protein ID WP_088872194.1
Coordinates 2661362..2661604 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y958_RS12195 2657733..2658413 + 681 WP_186291176.1 SDR family oxidoreductase -
Y958_RS12200 2658418..2659290 - 873 WP_088872193.1 phenylalanine 4-monooxygenase -
Y958_RS12205 2659439..2659930 - 492 WP_040848442.1 Lrp/AsnC family transcriptional regulator -
Y958_RS12210 2660141..2661208 + 1068 WP_088872629.1 4-hydroxyphenylpyruvate dioxygenase -
Y958_RS12215 2661362..2661604 + 243 WP_088872194.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Y958_RS12220 2661604..2661936 + 333 WP_088872195.1 endoribonuclease MazF Toxin
Y958_RS12225 2661943..2662785 - 843 WP_088872196.1 carbon-nitrogen hydrolase family protein -
Y958_RS12230 2662788..2663069 - 282 WP_088872197.1 glutaredoxin 3 -
Y958_RS12235 2663171..2663908 - 738 WP_088872630.1 ComF family protein -
Y958_RS12240 2664031..2664948 + 918 WP_088872198.1 methyltransferase domain-containing protein -
Y958_RS12245 2665017..2666936 - 1920 WP_088872199.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12041.89 Da        Isoelectric Point: 8.4982

>T78468 WP_088872195.1 NZ_CP022110:2661604-2661936 [Nitrospirillum amazonense CBAmc]
MGYIPDAGDVVWLQFNPQAGHEQAGHRPAVVLSPAAYNRRAGLLLCCPMTTQIKGYPFEVLIGPDKKQAVLADQVKSLDW
QARQAEFKGKIDDAELAEVRRKASALIGKP

Download         Length: 333 bp

>T78468 NZ_CP022110:2661604-2661936 [Nitrospirillum amazonense CBAmc]
ATGGGCTACATCCCGGATGCCGGGGATGTCGTGTGGCTGCAATTCAACCCGCAAGCGGGACACGAGCAGGCCGGACACCG
GCCGGCCGTGGTCCTAAGCCCAGCAGCCTACAATCGACGCGCCGGCTTGCTGCTGTGTTGTCCGATGACGACACAGATCA
AGGGTTATCCCTTCGAAGTGCTGATCGGGCCAGACAAGAAGCAGGCGGTCTTGGCCGACCAGGTGAAAAGCCTGGACTGG
CAGGCCCGACAGGCTGAGTTCAAAGGCAAGATCGACGACGCGGAGCTAGCAGAGGTTCGCCGCAAGGCCTCGGCCCTCAT
CGGCAAGCCGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8842.06 Da        Isoelectric Point: 4.4678

>AT78468 WP_088872194.1 NZ_CP022110:2661362-2661604 [Nitrospirillum amazonense CBAmc]
MRVTIRKWGNSASVRIPVAVMEAVGLEVDATVDIREEGNRIVIEPVRKDDYDLADLIAGITPENRHVEVDYGPSVGKEIP

Download         Length: 243 bp

>AT78468 NZ_CP022110:2661362-2661604 [Nitrospirillum amazonense CBAmc]
ATGCGCGTGACCATAAGGAAATGGGGAAACAGCGCCTCCGTCCGCATTCCCGTGGCAGTCATGGAAGCGGTTGGGCTGGA
GGTCGACGCCACAGTCGATATTCGGGAAGAGGGCAACCGCATCGTGATCGAGCCGGTGCGCAAGGACGACTACGATCTGG
CGGATTTGATTGCCGGCATAACTCCGGAAAATCGCCATGTCGAAGTCGACTACGGACCATCGGTCGGCAAGGAAATCCCG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References