Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2150487..2151095 Replicon chromosome
Accession NZ_CP022110
Organism Nitrospirillum amazonense CBAmc

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Y958_RS09910 Protein ID WP_088871849.1
Coordinates 2150916..2151095 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Y958_RS09905 Protein ID WP_088871848.1
Coordinates 2150487..2150894 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y958_RS09880 2145770..2145985 - 216 WP_088871844.1 ribbon-helix-helix domain-containing protein -
Y958_RS09885 2145982..2147280 - 1299 WP_088871845.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -
Y958_RS09890 2147283..2148350 - 1068 WP_211098595.1 biotin synthase BioB -
Y958_RS09895 2148608..2149789 + 1182 WP_088871846.1 8-amino-7-oxononanoate synthase -
Y958_RS09900 2149786..2150484 + 699 WP_088871847.1 dethiobiotin synthase -
Y958_RS09905 2150487..2150894 - 408 WP_088871848.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Y958_RS09910 2150916..2151095 - 180 WP_088871849.1 type II toxin-antitoxin system HicA family toxin Toxin
Y958_RS09915 2151151..2151381 - 231 WP_040847285.1 hypothetical protein -
Y958_RS09920 2151493..2152899 - 1407 WP_088871850.1 class II fumarate hydratase -
Y958_RS09925 2152962..2154002 - 1041 WP_088871851.1 AIM24 family protein -
Y958_RS09930 2154357..2155139 + 783 WP_088871852.1 TerB family tellurite resistance protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-125)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6553.75 Da        Isoelectric Point: 11.5947

>T78467 WP_088871849.1 NZ_CP022110:c2151095-2150916 [Nitrospirillum amazonense CBAmc]
MESVDLIRELQAVGWVLNRVRGSHHVFKHPHRPGTLVVPHPKKDLGMGLVAAIRKQAGL

Download         Length: 180 bp

>T78467 NZ_CP022110:c2151095-2150916 [Nitrospirillum amazonense CBAmc]
ATGGAAAGTGTCGACCTTATCCGGGAACTTCAGGCGGTAGGTTGGGTGTTGAATCGTGTGCGCGGTTCGCACCATGTCTT
CAAGCACCCGCATCGCCCTGGGACCCTGGTGGTCCCCCATCCCAAGAAGGATTTGGGCATGGGCTTGGTCGCCGCCATCC
GCAAGCAGGCGGGGTTATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14418.39 Da        Isoelectric Point: 4.5268

>AT78467 WP_088871848.1 NZ_CP022110:c2150894-2150487 [Nitrospirillum amazonense CBAmc]
MRYPVVIEPGDEATAYGVAVPDLPGCFSAGDTLDEALKAAEEAAAAWLDATLDEGGAVPSASPLEALRANPHYVGWIFAM
IEVDPAVLDDKVERVNITLPRRVLRRLDVLAKAAGETRSGYISSLTLREAGRKRA

Download         Length: 408 bp

>AT78467 NZ_CP022110:c2150894-2150487 [Nitrospirillum amazonense CBAmc]
ATGCGGTATCCCGTGGTGATCGAGCCGGGTGATGAGGCCACCGCCTATGGCGTGGCTGTTCCCGATCTGCCGGGCTGCTT
TTCGGCCGGCGATACGCTGGATGAGGCGCTGAAGGCAGCGGAGGAAGCGGCCGCCGCCTGGCTGGACGCCACGCTGGATG
AGGGTGGGGCTGTTCCATCTGCCTCTCCCCTGGAGGCGCTGCGGGCCAACCCCCACTATGTCGGCTGGATCTTCGCCATG
ATCGAGGTCGATCCCGCCGTGCTGGACGACAAGGTGGAACGTGTGAACATCACCCTGCCGCGGCGCGTTCTGCGCCGCCT
GGACGTTCTGGCCAAAGCTGCGGGTGAAACCCGCTCCGGCTATATCTCTTCCCTGACCCTGCGGGAGGCTGGGCGCAAGC
GCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References