Detailed information of TA system TA078453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 555091..555857
• Replicon: chromosome
• Accession: NZ_CP022104
• Organism: Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CEQ50_RS17410
• Protein ID: WP_088733355.1
• Coordinates: 555091..555588 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A318A958
• Locus tag: CEQ50_RS17415
• Protein ID: WP_010319336.1
• Coordinates: 555585..555857 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ50_RS17380	550187..550939	+	753	WP_064626957.1	SDR family oxidoreductase	-
CEQ50_RS17385	550943..551053	+	111	WP_081265643.1	DUF3265 domain-containing protein	-
CEQ50_RS17390	551575..551874	-	300	WP_088733354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEQ50_RS17395	551882..552124	-	243	WP_017045808.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CEQ50_RS17400	552998..554175	+	1178	WP_088733270.1	IS3 family transposase	-
CEQ50_RS17405	554181..554951	+	771	Protein_541	hypothetical protein	-
CEQ50_RS17410	555091..555588	-	498	WP_088733355.1	GNAT family N-acetyltransferase	Toxin
CEQ50_RS17415	555585..555857	-	273	WP_010319336.1	DUF1778 domain-containing protein	Antitoxin
CEQ50_RS17420	555897..556058	+	162	WP_088733356.1	DUF3265 domain-containing protein	-
CEQ50_RS17435	556243..556425	+	183	WP_088733358.1	DUF645 family protein	-
CEQ50_RS20100	557028..557447	+	420	WP_198300529.1	DUF1778 domain-containing protein	-
CEQ50_RS17455	557444..557977	+	534	WP_017045662.1	GNAT family N-acetyltransferase	-
CEQ50_RS17460	558134..558448	+	315	WP_017045663.1	hypothetical protein	-
CEQ50_RS17465	558526..559368	+	843	WP_088733361.1	hypothetical protein	-
CEQ50_RS20025	559353..559532	-	180	Protein_550	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	547574..572505	24931
	-	inside	Integron	-	-	416630..557447	140817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18496.24 Da
• Isoelectric Point: 9.2813

>T78453 WP_088733355.1 NZ_CP022104:c555588-555091 [Vibrio anguillarum]
MMKTALLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Nucleotide

• Length: 498 bp

>T78453 NZ_CP022104:c555588-555091 [Vibrio anguillarum]
ATGATGAAAACGGCATTACTCGATAAAGATAAACACGACAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTCATGGCAAGTCAGCAAGCTAAAAAAGATAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACCTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAACATTGCCTGATAAGTTACAGAAAAAGCATCAG
TCATCAACTTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGATAGCTATAAAGGTAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCAGCTAGTGATAGCGTGGCATTTCCCGTCGTTATTGTTGACGCAAAAGATGGCG
CCAAACATTTCTATGAGCGCTATGGTTTTAAAGCGTTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGCTTGGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9859.43 Da
• Isoelectric Point: 9.7681

>AT78453 WP_010319336.1 NZ_CP022104:c555857-555585 [Vibrio anguillarum]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQADAILLMEALDKPTTLNQKLKT
AAERYETKTQ

Nucleotide

• Length: 273 bp

>AT78453 NZ_CP022104:c555857-555585 [Vibrio anguillarum]
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTCGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAACAAGTGATTGAACGCGAGCAAACAC
TAAAATTAAGCCAAGCAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAAAACCCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A318A958