Detailed information of TA system TA078452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 551575..552124
• Replicon: chromosome
• Accession: NZ_CP022104
• Organism: Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CEQ50_RS17390
• Protein ID: WP_088733354.1
• Coordinates: 551575..551874 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A233HQC6
• Locus tag: CEQ50_RS17395
• Protein ID: WP_017045808.1
• Coordinates: 551882..552124 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ50_RS17360	547574..547921	+	348	WP_017042813.1	DUF3024 domain-containing protein	-
CEQ50_RS17370	548083..548715	+	633	WP_088733352.1	hypothetical protein	-
CEQ50_RS17375	548911..549276	+	366	WP_088733353.1	hypothetical protein	-
CEQ50_RS17380	550187..550939	+	753	WP_064626957.1	SDR family oxidoreductase	-
CEQ50_RS17385	550943..551053	+	111	WP_081265643.1	DUF3265 domain-containing protein	-
CEQ50_RS17390	551575..551874	-	300	WP_088733354.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ50_RS17395	551882..552124	-	243	WP_017045808.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEQ50_RS17400	552998..554175	+	1178	WP_088733270.1	IS3 family transposase	-
CEQ50_RS17405	554181..554951	+	771	Protein_541	hypothetical protein	-
CEQ50_RS17410	555091..555588	-	498	WP_088733355.1	GNAT family N-acetyltransferase	-
CEQ50_RS17415	555585..555857	-	273	WP_010319336.1	DUF1778 domain-containing protein	-
CEQ50_RS17420	555897..556058	+	162	WP_088733356.1	DUF3265 domain-containing protein	-
CEQ50_RS17435	556243..556425	+	183	WP_088733358.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	547574..572505	24931
	-	inside	Integron	-	-	416630..557447	140817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11430.11 Da
• Isoelectric Point: 9.8455

>T78452 WP_088733354.1 NZ_CP022104:c551874-551575 [Vibrio anguillarum]
MNKNKYKLSKLAQAHLHKIKNYTITNFSEMQWNAYKDTLLTGFQMLADNPAVGRSCNDLYQNGFYFPIGKHTAYFTKEDS
FILVVAVLGQSQLPQNHLR

Nucleotide

• Length: 300 bp

>T78452 NZ_CP022104:c551874-551575 [Vibrio anguillarum]
ATGAACAAGAATAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACATAAAATCAAAAATTATACCATTACAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGATACTCTTCTTACTGGGTTTCAGATGCTCGCTGACAACCCAGCGGTAGGCA
GAAGCTGCAACGATTTATATCAAAATGGTTTTTACTTCCCTATAGGCAAGCATACGGCTTACTTTACCAAGGAAGACAGC
TTTATTTTGGTCGTTGCAGTCCTTGGACAATCTCAATTGCCACAAAACCATCTGCGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9036.28 Da
• Isoelectric Point: 4.7672

>AT78452 WP_017045808.1 NZ_CP022104:c552124-551882 [Vibrio anguillarum]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELEVMKADYIKHCFESAKADLAQGNIVDGENFLNAL

Nucleotide

• Length: 243 bp

>AT78452 NZ_CP022104:c552124-551882 [Vibrio anguillarum]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAACAATAAAGATGCCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGTCATGAAAGCCGATTACA
TAAAACATTGTTTTGAGTCCGCAAAAGCAGACTTAGCCCAAGGCAATATAGTTGACGGTGAAAATTTCCTAAACGCGTTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A233HQC6