Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 545134..545672 Replicon chromosome
Accession NZ_CP022104
Organism Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)


Gene name parE Uniprot ID A0A7X8U0Q7
Locus tag CEQ50_RS17340 Protein ID WP_019282621.1
Coordinates 545134..545433 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7X8YM83
Locus tag CEQ50_RS17345 Protein ID WP_017045414.1
Coordinates 545430..545672 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ50_RS17300 540793..541074 + 282 WP_198300532.1 hypothetical protein -
CEQ50_RS17305 541267..541950 + 684 WP_088733349.1 hypothetical protein -
CEQ50_RS17310 542547..542837 - 291 WP_017044325.1 type II toxin-antitoxin system RelE/ParE family toxin -
CEQ50_RS17315 542830..543051 - 222 WP_017044326.1 hypothetical protein -
CEQ50_RS17320 543797..544294 + 498 WP_088733350.1 GNAT family N-acetyltransferase -
CEQ50_RS17325 544291..544401 + 111 WP_088733613.1 DUF3265 domain-containing protein -
CEQ50_RS17330 544445..544999 + 555 WP_088733351.1 sugar O-acetyltransferase -
CEQ50_RS17335 545049..545126 + 78 WP_157724339.1 DUF3265 domain-containing protein -
CEQ50_RS17340 545134..545433 - 300 WP_019282621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ50_RS17345 545430..545672 - 243 WP_017045414.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CEQ50_RS17350 545756..545855 + 100 Protein_532 DUF3265 domain-containing protein -
CEQ50_RS17360 547574..547921 + 348 WP_017042813.1 DUF3024 domain-containing protein -
CEQ50_RS17370 548083..548715 + 633 WP_088733352.1 hypothetical protein -
CEQ50_RS17375 548911..549276 + 366 WP_088733353.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 547574..572505 24931
- inside Integron - - 416630..557447 140817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.38 Da        Isoelectric Point: 9.8917

>T78451 WP_019282621.1 NZ_CP022104:c545433-545134 [Vibrio anguillarum]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T78451 NZ_CP022104:c545433-545134 [Vibrio anguillarum]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTCCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.89 Da        Isoelectric Point: 4.2213

>AT78451 WP_017045414.1 NZ_CP022104:c545672-545430 [Vibrio anguillarum]
MAKNTSITLGDHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK

Download         Length: 243 bp

>AT78451 NZ_CP022104:c545672-545430 [Vibrio anguillarum]
ATGGCTAAAAATACTAGCATCACTCTCGGCGACCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8YM83

References