Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 537220..537767 Replicon chromosome
Accession NZ_CP022104
Organism Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)


Gene name relE Uniprot ID A0A223N2K4
Locus tag CEQ50_RS17270 Protein ID WP_000229324.1
Coordinates 537465..537767 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag CEQ50_RS17265 Protein ID WP_000861987.1
Coordinates 537220..537477 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEQ50_RS17220 532350..532796 + 447 WP_088733341.1 hypothetical protein -
CEQ50_RS17225 532942..533541 + 600 WP_088733342.1 pentapeptide repeat-containing protein -
CEQ50_RS17230 533757..533993 - 237 WP_088729611.1 RNA recognition motif containing protein -
CEQ50_RS17235 534235..535044 + 810 WP_088733343.1 TIR domain-containing protein -
CEQ50_RS17240 535315..535704 + 390 WP_019280976.1 DUF1090 domain-containing protein -
CEQ50_RS17245 535708..535821 + 114 WP_088733344.1 DUF3265 domain-containing protein -
CEQ50_RS17255 535942..536367 + 426 WP_088733345.1 hypothetical protein -
CEQ50_RS17260 536520..537026 + 507 WP_088733346.1 GNAT family N-acetyltransferase -
CEQ50_RS17265 537220..537477 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CEQ50_RS17270 537465..537767 + 303 WP_000229324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEQ50_RS17280 538400..538759 + 360 WP_013868602.1 VOC family protein -
CEQ50_RS17290 539310..540119 + 810 WP_157724334.1 hypothetical protein -
CEQ50_RS17300 540793..541074 + 282 WP_198300532.1 hypothetical protein -
CEQ50_RS17305 541267..541950 + 684 WP_088733349.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 416630..557447 140817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11795.70 Da        Isoelectric Point: 4.9166

>T78450 WP_000229324.1 NZ_CP022104:537465-537767 [Vibrio anguillarum]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T78450 NZ_CP022104:537465-537767 [Vibrio anguillarum]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGATCTGAATGATATTGCTGAATACATCGCACTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCAC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCATGTCGTGTTTTCTATAAGTATGATGATGAAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTACGTCGGTTAATGCTAACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT78450 WP_000861987.1 NZ_CP022104:537220-537477 [Vibrio anguillarum]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT78450 NZ_CP022104:537220-537477 [Vibrio anguillarum]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAGCCGTCAGCTTACCTTATTGATGTAGACGATTATGAATTTATGCAAAATCGTTTAGCGA
TCCTCGAAGGCATTGCTCGTGGCGAGCGAGCTCTGGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A223N2K4

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References