Detailed information of TA system TA078449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 488277..488836
• Replicon: chromosome
• Accession: NZ_CP022104
• Organism: Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7YRQ7
• Locus tag: CEQ50_RS16850
• Protein ID: WP_010320663.1
• Coordinates: 488277..488555 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A233HRF0
• Locus tag: CEQ50_RS16855
• Protein ID: WP_017040620.1
• Coordinates: 488552..488836 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ50_RS16800	483744..484166	+	423	WP_088733299.1	hypothetical protein	-
CEQ50_RS16805	484202..484312	+	111	WP_088733602.1	DUF3265 domain-containing protein	-
CEQ50_RS16810	484350..485054	+	705	WP_088733300.1	hypothetical protein	-
CEQ50_RS20000	485051..485161	+	111	Protein_441	DUF3265 domain-containing protein	-
CEQ50_RS16815	485201..485626	+	426	WP_088733301.1	hypothetical protein	-
CEQ50_RS16825	486348..486983	+	636	WP_088733302.1	CatB-related O-acetyltransferase	-
CEQ50_RS16835	487135..487586	+	452	Protein_444	GNAT family N-acetyltransferase	-
CEQ50_RS16840	487583..487693	+	111	WP_072599357.1	DUF3265 domain-containing protein	-
CEQ50_RS16850	488277..488555	-	279	WP_010320663.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CEQ50_RS16855	488552..488836	-	285	WP_017040620.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CEQ50_RS16860	489047..490045	+	999	WP_088733303.1	DUF4238 domain-containing protein	-
CEQ50_RS16870	490197..490700	+	504	WP_088733304.1	peptide deformylase	-
CEQ50_RS16875	490910..491590	-	681	WP_088733305.1	hypothetical protein	-
CEQ50_RS16880	491671..491805	+	135	WP_088733606.1	DUF3265 domain-containing protein	-
CEQ50_RS16885	491835..492386	+	552	WP_088733306.1	VRR-NUC domain-containing protein	-
CEQ50_RS16890	492524..493102	+	579	WP_198300526.1	DJ-1/PfpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	473898..490700	16802
	-	inside	Integron	-	-	416630..557447	140817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10878.58 Da
• Isoelectric Point: 4.3430

>T78449 WP_010320663.1 NZ_CP022104:c488555-488277 [Vibrio anguillarum]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDDIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGSIIRIM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T78449 NZ_CP022104:c488555-488277 [Vibrio anguillarum]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAGAAGATCTTCGAGTTTCTTTATGACTTTAACCCTGATGCGGC
TGAAAAAACTGATGACATTATTGAGGCTAAAGTAGAAAACTTACTCGAACAACCATTGATGGGTGTTCAACGGGATGGAA
TTCGAGGACGATTGCTCATTATTCCCGAAATCTCAATGATCGTTTCGTACTGGGTAGAAGGTTCAATTATTCGCATAATG
CGAGTTCTACACCAGAAGCAGAAATTCCCTACCGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10957.29 Da
• Isoelectric Point: 9.2173

>AT78449 WP_017040620.1 NZ_CP022104:c488836-488552 [Vibrio anguillarum]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDAWLTEQINLAFEKFDSGKSSFVEHNSAKAR
MAERKAKIRNRGQQ

Nucleotide

• Length: 285 bp

>AT78449 NZ_CP022104:c488836-488552 [Vibrio anguillarum]
ATGGACACTAGAATTCAATTTCGTGTTGATGACGAAATTAAACGTTTAGCCCAACAAATGGCTGAGAGCCAAGGTCGCAC
ACTCAGCGACGCTTGCCGTGAACTTACTGAACAAATGGCTGAGCAACAAAGAAAAACATTATCTCATGACGCTTGGTTAA
CTGAACAAATAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTTCATTTGTTGAACATAATTCAGCTAAAGCACGA
ATGGCTGAACGAAAGGCCAAAATTCGTAATCGAGGCCAGCAATGA

Structures

Toxin

• AlphaFold DB: A0A0F2IQF3

Antitoxin

• AlphaFold DB: A0A233HRF0