Detailed information of TA system TA078448

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 476300..476865
• Replicon: chromosome
• Accession: NZ_CP022104
• Organism: Vibrio anguillarum strain CNEVA NB11008

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEQ50_RS16745
• Protein ID: WP_088733294.1
• Coordinates: 476578..476865 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CEQ50_RS16740
• Protein ID: WP_164996843.1
• Coordinates: 476300..476581 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ50_RS16690	471674..472612	+	939	WP_088733289.1	hypothetical protein	-
CEQ50_RS16700	472744..473229	+	486	WP_088733290.1	GNAT family N-acetyltransferase	-
CEQ50_RS19985	473226..473336	+	111	Protein_419	DUF3265 domain-containing protein	-
CEQ50_RS16710	473364..473750	+	387	WP_045569085.1	hypothetical protein	-
CEQ50_RS16720	473898..474431	+	534	WP_045570179.1	adenylate kinase	-
CEQ50_RS16725	474581..475117	+	537	WP_088733291.1	GNAT family N-acetyltransferase	-
CEQ50_RS16730	475327..476094	+	768	WP_088733292.1	hypothetical protein	-
CEQ50_RS16740	476300..476581	+	282	WP_164996843.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEQ50_RS16745	476578..476865	+	288	WP_088733294.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEQ50_RS16750	476875..476985	+	111	WP_088129430.1	DUF3265 domain-containing protein	-
CEQ50_RS16755	477010..477300	-	291	WP_017044325.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CEQ50_RS16760	477293..477514	-	222	WP_088733295.1	hypothetical protein	-
CEQ50_RS16765	478238..478903	+	666	WP_088733296.1	hypothetical protein	-
CEQ50_RS16770	479204..479722	+	519	WP_029628793.1	hypothetical protein	-
CEQ50_RS19990	479724..479834	+	111	Protein_431	DUF3265 domain-containing protein	-
CEQ50_RS16775	480399..480956	+	558	WP_088733297.1	hypothetical protein	-
CEQ50_RS16780	481090..481626	+	537	WP_088733269.1	nucleotidyltransferase family protein	-
CEQ50_RS16785	481623..481733	+	111	WP_088729824.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	473898..490700	16802
	-	inside	Integron	-	-	416630..557447	140817

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10939.73 Da
• Isoelectric Point: 5.6023

>T78448 WP_088733294.1 NZ_CP022104:476578-476865 [Vibrio anguillarum]
MKVVWSPLALQKLGDAAEFIVLDNPSAAEKWVNDVFDKTELLGSMPEMGRMVPEIPHTNYREIIFGHYRIIYSLGLEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T78448 NZ_CP022104:476578-476865 [Vibrio anguillarum]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTTGGTGATGCCGCAGAGTTTATTGTTTTGGATAACCCCTCAGC
TGCAGAAAAGTGGGTGAATGATGTGTTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATACCTCATACGAACTACCGTGAAATAATTTTTGGCCATTACCGCATTATTTATAGTTTGGGCCTCGAAATACGTGTT
CTAACAGTCCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10361.93 Da
• Isoelectric Point: 5.1548

>AT78448 WP_164996843.1 NZ_CP022104:476300-476581 [Vibrio anguillarum]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQILGRIIK

Nucleotide

• Length: 282 bp

>AT78448 NZ_CP022104:476300-476581 [Vibrio anguillarum]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAAACTCGTCGACCATTAGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTTGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTGGGTGTATCAAAC
GAAGATGCTCGTTCACAAATTCTGGGACGCATCATCAAATGA