Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 504284..505050 Replicon chromosome
Accession NZ_CP022102
Organism Vibrio anguillarum strain JLL237

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag CEJ46_RS16905 Protein ID WP_013867769.1
Coordinates 504284..504781 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag CEJ46_RS16910 Protein ID WP_013867770.1
Coordinates 504778..505050 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEJ46_RS16870 499621..500079 + 459 WP_064626941.1 DMT family transporter -
CEJ46_RS16875 500079..500504 + 426 WP_017050349.1 DMT family transporter -
CEJ46_RS16880 500669..500947 - 279 WP_045569735.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
CEJ46_RS16885 500944..501228 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CEJ46_RS19865 501255..501395 + 141 Protein_473 DUF3265 domain-containing protein -
CEJ46_RS16895 501947..502573 + 627 WP_064626942.1 hypothetical protein -
CEJ46_RS16900 503713..504129 + 417 WP_081265642.1 GNAT family N-acetyltransferase -
CEJ46_RS16905 504284..504781 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
CEJ46_RS16910 504778..505050 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
CEJ46_RS16920 505819..506232 + 414 WP_064626946.1 hypothetical protein -
CEJ46_RS16930 506379..506912 + 534 WP_064626947.1 cysteine hydrolase -
CEJ46_RS16935 507062..507548 + 487 Protein_480 GNAT family N-acetyltransferase -
CEJ46_RS16940 507545..507656 + 112 Protein_481 DUF3265 domain-containing protein -
CEJ46_RS16945 507696..508166 + 471 WP_064626948.1 GNAT family N-acetyltransferase -
CEJ46_RS16950 508163..508273 + 111 WP_072612519.1 DUF3265 domain-containing protein -
CEJ46_RS16955 508301..508816 + 516 WP_064626949.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 378437..533861 155424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T78445 WP_013867769.1 NZ_CP022102:c504781-504284 [Vibrio anguillarum]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T78445 NZ_CP022102:c504781-504284 [Vibrio anguillarum]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT78445 WP_013867770.1 NZ_CP022102:c505050-504778 [Vibrio anguillarum]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT78445 NZ_CP022102:c505050-504778 [Vibrio anguillarum]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATTGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References