Detailed information of TA system TA078444

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 500669..501228
• Replicon: chromosome
• Accession: NZ_CP022102
• Organism: Vibrio anguillarum strain JLL237

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F2I776
• Locus tag: CEJ46_RS16880
• Protein ID: WP_045569735.1
• Coordinates: 500669..500947 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: CEJ46_RS16885
• Protein ID: WP_000381183.1
• Coordinates: 500944..501228 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEJ46_RS16845	497236..497499	+	264	WP_064626938.1	hypothetical protein	-
CEJ46_RS16850	497507..497617	+	111	WP_088721585.1	DUF3265 domain-containing protein	-
CEJ46_RS16855	497664..498020	+	357	WP_045570554.1	hypothetical protein	-
CEJ46_RS19985	498102..498359	-	258	WP_064626939.1	hypothetical protein	-
CEJ46_RS19860	498522..498641	+	120	WP_088729621.1	hypothetical protein	-
CEJ46_RS16865	498608..499528	-	921	WP_064626940.1	LysR family transcriptional regulator	-
CEJ46_RS16870	499621..500079	+	459	WP_064626941.1	DMT family transporter	-
CEJ46_RS16875	500079..500504	+	426	WP_017050349.1	DMT family transporter	-
CEJ46_RS16880	500669..500947	-	279	WP_045569735.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CEJ46_RS16885	500944..501228	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CEJ46_RS19865	501255..501395	+	141	Protein_473	DUF3265 domain-containing protein	-
CEJ46_RS16895	501947..502573	+	627	WP_064626942.1	hypothetical protein	-
CEJ46_RS16900	503713..504129	+	417	WP_081265642.1	GNAT family N-acetyltransferase	-
CEJ46_RS16905	504284..504781	-	498	WP_013867769.1	GNAT family N-acetyltransferase	-
CEJ46_RS16910	504778..505050	-	273	WP_013867770.1	DUF1778 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	378437..533861	155424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10898.61 Da
• Isoelectric Point: 4.6794

>T78444 WP_045569735.1 NZ_CP022102:c500947-500669 [Vibrio anguillarum]
MIFWEEASLNDREKIFEFLYDFNPTAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T78444 NZ_CP022102:c500947-500669 [Vibrio anguillarum]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGAGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAACCGCAGC
TGAAAAAACGGATGAGCTCATAGAAACAAAAGTTGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGTA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT78444 WP_000381183.1 NZ_CP022102:c501228-500944 [Vibrio anguillarum]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT78444 NZ_CP022102:c501228-500944 [Vibrio anguillarum]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGTTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Structures

Toxin

• AlphaFold DB: A0A0F2I776

Antitoxin

• AlphaFold DB: A0A067BL33