Detailed information of TA system TA078443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 423050..423599
• Replicon: chromosome
• Accession: NZ_CP022102
• Organism: Vibrio anguillarum strain JLL237

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A191WAE5
• Locus tag: CEJ46_RS16330
• Protein ID: WP_017049509.1
• Coordinates: 423050..423349 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A191WAH2
• Locus tag: CEJ46_RS16335
• Protein ID: WP_064626856.1
• Coordinates: 423357..423599 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEJ46_RS16295	418564..418833	-	270	WP_000277238.1	type II toxin-antitoxin system YafQ family toxin	-
CEJ46_RS16300	418826..419104	-	279	WP_001258569.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
CEJ46_RS16310	420410..420532	+	123	WP_088721536.1	DUF3265 domain-containing protein	-
CEJ46_RS16315	420584..421417	+	834	WP_064626851.1	bacteriophage abortive infection AbiH family protein	-
CEJ46_RS19830	421401..421514	+	114	Protein_373	histone acetyltransferase	-
CEJ46_RS16320	421659..422201	+	543	WP_064626852.1	hypothetical protein	-
CEJ46_RS16325	422346..422882	+	537	WP_064626854.1	nucleotidyltransferase family protein	-
CEJ46_RS16330	423050..423349	-	300	WP_017049509.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEJ46_RS16335	423357..423599	-	243	WP_064626856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEJ46_RS16340	423907..424143	-	237	WP_064626858.1	RNA recognition motif containing protein	-
CEJ46_RS16345	424393..424857	+	465	WP_064626859.1	ASCH domain-containing protein	-
CEJ46_RS16350	424850..424972	+	123	WP_081265636.1	DUF3265 domain-containing protein	-
CEJ46_RS16365	426642..427559	+	918	WP_064626861.1	alpha/beta hydrolase	-
CEJ46_RS16370	427562..427672	+	111	WP_081265638.1	DUF3265 domain-containing protein	-
CEJ46_RS16375	427712..428173	+	462	WP_064626862.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	378437..533861	155424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11412.09 Da
• Isoelectric Point: 9.8456

>T78443 WP_017049509.1 NZ_CP022102:c423349-423050 [Vibrio anguillarum]
MHKSKYKLSKLAQAHLHKIKNYTVTNFSEMQWNAYKDTLLTGFQMLADNPAVGRSCNDLYQNGFYFPIGKHTAYFTKEDS
FILVVAVLGQSQLPQNHLR

Nucleotide

• Length: 300 bp

>T78443 NZ_CP022102:c423349-423050 [Vibrio anguillarum]
ATGCACAAGAGTAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACATAAAATCAAAAATTATACCGTTACAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGATACTCTTCTTACTGGGTTTCAGATGCTCGCAGATAACCCAGCGGTAGGCA
GAAGCTGCAACGATTTATATCAAAATGGTTTTTACTTCCCTATAGGCAAGCATACGGCTTACTTTACCAAGGAAGACAGC
TTTATTTTGGTCGTTGCAGTCCTTGGACAATCGCAATTGCCACAAAACCATCTGCGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9066.30 Da
• Isoelectric Point: 4.7672

>AT78443 WP_064626856.1 NZ_CP022102:c423599-423357 [Vibrio anguillarum]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDTVVVMSIRDYEELEVMKADYIKHCFESAKADLAQGNIVDGENFLNAL

Nucleotide

• Length: 243 bp

>AT78443 NZ_CP022102:c423599-423357 [Vibrio anguillarum]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAATAATAAAGATACCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGTCATGAAAGCCGATTACA
TAAAACATTGTTTTGAGTCCGCAAAAGCAGACTTAGCCCAAGGCAATATAGTTGACGGTGAAAATTTCCTAAACGCGTTG
TAA

Structures

Toxin

• AlphaFold DB: A0A191WAE5

Antitoxin

• AlphaFold DB: A0A191WAH2