Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 418564..419104 Replicon chromosome
Accession NZ_CP022102
Organism Vibrio anguillarum strain JLL237

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag CEJ46_RS16295 Protein ID WP_000277238.1
Coordinates 418564..418833 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag CEJ46_RS16300 Protein ID WP_001258569.1
Coordinates 418826..419104 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEJ46_RS16245 414033..414160 + 128 Protein_359 DUF3265 domain-containing protein -
CEJ46_RS16250 414501..414623 + 123 WP_081265635.1 DUF3265 domain-containing protein -
CEJ46_RS16255 414682..415125 + 444 WP_064626843.1 hypothetical protein -
CEJ46_RS16260 415342..416229 + 888 WP_020840769.1 hypothetical protein -
CEJ46_RS16265 416216..416632 + 417 WP_020840768.1 hypothetical protein -
CEJ46_RS19970 416647..416739 + 93 WP_004402681.1 DUF3265 domain-containing protein -
CEJ46_RS16275 416821..417078 + 258 WP_045569027.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CEJ46_RS16280 417066..417368 + 303 WP_064626847.1 type II toxin-antitoxin system RelE/ParE family toxin -
CEJ46_RS16285 417590..417892 + 303 WP_064626849.1 hypothetical protein -
CEJ46_RS16295 418564..418833 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
CEJ46_RS16300 418826..419104 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CEJ46_RS16310 420410..420532 + 123 WP_088721536.1 DUF3265 domain-containing protein -
CEJ46_RS16315 420584..421417 + 834 WP_064626851.1 bacteriophage abortive infection AbiH family protein -
CEJ46_RS19830 421401..421514 + 114 Protein_373 histone acetyltransferase -
CEJ46_RS16320 421659..422201 + 543 WP_064626852.1 hypothetical protein -
CEJ46_RS16325 422346..422882 + 537 WP_064626854.1 nucleotidyltransferase family protein -
CEJ46_RS16330 423050..423349 - 300 WP_017049509.1 type II toxin-antitoxin system RelE/ParE family toxin -
CEJ46_RS16335 423357..423599 - 243 WP_064626856.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 378437..533861 155424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T78442 WP_000277238.1 NZ_CP022102:c418833-418564 [Vibrio anguillarum]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T78442 NZ_CP022102:c418833-418564 [Vibrio anguillarum]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT78442 WP_001258569.1 NZ_CP022102:c419104-418826 [Vibrio anguillarum]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT78442 NZ_CP022102:c419104-418826 [Vibrio anguillarum]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References