Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 416821..417368 | Replicon | chromosome |
| Accession | NZ_CP022102 | ||
| Organism | Vibrio anguillarum strain JLL237 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A191WAC2 |
| Locus tag | CEJ46_RS16280 | Protein ID | WP_064626847.1 |
| Coordinates | 417066..417368 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0F2IS57 |
| Locus tag | CEJ46_RS16275 | Protein ID | WP_045569027.1 |
| Coordinates | 416821..417078 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEJ46_RS16220 | 412197..412319 | + | 123 | WP_081265634.1 | DUF3265 domain-containing protein | - |
| CEJ46_RS16225 | 412342..413004 | + | 663 | WP_064626837.1 | hypothetical protein | - |
| CEJ46_RS16230 | 413159..413554 | + | 396 | WP_064626839.1 | DUF3465 domain-containing protein | - |
| CEJ46_RS16235 | 413555..413689 | + | 135 | Protein_358 | DUF3265 domain-containing protein | - |
| CEJ46_RS16245 | 414033..414160 | + | 128 | Protein_359 | DUF3265 domain-containing protein | - |
| CEJ46_RS16250 | 414501..414623 | + | 123 | WP_081265635.1 | DUF3265 domain-containing protein | - |
| CEJ46_RS16255 | 414682..415125 | + | 444 | WP_064626843.1 | hypothetical protein | - |
| CEJ46_RS16260 | 415342..416229 | + | 888 | WP_020840769.1 | hypothetical protein | - |
| CEJ46_RS16265 | 416216..416632 | + | 417 | WP_020840768.1 | hypothetical protein | - |
| CEJ46_RS19970 | 416647..416739 | + | 93 | WP_004402681.1 | DUF3265 domain-containing protein | - |
| CEJ46_RS16275 | 416821..417078 | + | 258 | WP_045569027.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| CEJ46_RS16280 | 417066..417368 | + | 303 | WP_064626847.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CEJ46_RS16285 | 417590..417892 | + | 303 | WP_064626849.1 | hypothetical protein | - |
| CEJ46_RS16295 | 418564..418833 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
| CEJ46_RS16300 | 418826..419104 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| CEJ46_RS16310 | 420410..420532 | + | 123 | WP_088721536.1 | DUF3265 domain-containing protein | - |
| CEJ46_RS16315 | 420584..421417 | + | 834 | WP_064626851.1 | bacteriophage abortive infection AbiH family protein | - |
| CEJ46_RS19830 | 421401..421514 | + | 114 | Protein_373 | histone acetyltransferase | - |
| CEJ46_RS16320 | 421659..422201 | + | 543 | WP_064626852.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 378437..533861 | 155424 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11668.63 Da Isoelectric Point: 6.9806
>T78441 WP_064626847.1 NZ_CP022102:417066-417368 [Vibrio anguillarum]
MAKLIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAKLIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T78441 NZ_CP022102:417066-417368 [Vibrio anguillarum]
ATGGCTAAACTAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATTGCTGAATACATCGCACTTGAAAATATTGT
TGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATACCAC
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTTTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA
ATGGCTAAACTAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATTGCTGAATACATCGCACTTGAAAATATTGT
TGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATACCAC
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTTTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9578.00 Da Isoelectric Point: 6.2254
>AT78441 WP_045569027.1 NZ_CP022102:416821-417078 [Vibrio anguillarum]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAISHDEAKDKM
SKWLN
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKAISHDEAKDKM
SKWLN
Download Length: 258 bp
>AT78441 NZ_CP022102:416821-417078 [Vibrio anguillarum]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGATTATGAGTTTATGCAAAATCGTTTGGCTA
TTCTTGAGGGTATTGCGCGAGGTGAACGCGCACTAGCTGACGGTAAAGCTATAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTAAACTAA
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACCGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGATTATGAGTTTATGCAAAATCGTTTGGCTA
TTCTTGAGGGTATTGCGCGAGGTGAACGCGCACTAGCTGACGGTAAAGCTATAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTAAACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A191WAC2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F2IS57 |