Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 634252..634811 Replicon chromosome
Accession NZ_CP022100
Organism Vibrio anguillarum strain S3 4/9

Toxin (Protein)


Gene name relE Uniprot ID A0A0F2I776
Locus tag CEG15_RS16945 Protein ID WP_045569735.1
Coordinates 634252..634530 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag CEG15_RS16950 Protein ID WP_000381183.1
Coordinates 634527..634811 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEG15_RS16900 629439..629864 + 426 WP_045571622.1 GNAT family N-acetyltransferase -
CEG15_RS16910 630480..631106 + 627 WP_088729618.1 hypothetical protein -
CEG15_RS16920 631738..632019 + 282 WP_198302712.1 hypothetical protein -
CEG15_RS16925 632105..632224 + 120 WP_088729621.1 hypothetical protein -
CEG15_RS16930 632191..633111 - 921 WP_064626940.1 LysR family transcriptional regulator -
CEG15_RS16935 633204..633662 + 459 WP_064626941.1 DMT family transporter -
CEG15_RS16940 633662..634087 + 426 WP_017050349.1 DMT family transporter -
CEG15_RS16945 634252..634530 - 279 WP_045569735.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CEG15_RS16950 634527..634811 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CEG15_RS19735 634838..634978 + 141 Protein_626 DUF3265 domain-containing protein -
CEG15_RS16960 634942..635820 + 879 WP_198302717.1 hypothetical protein -
CEG15_RS16965 635978..636385 + 408 WP_175418697.1 hypothetical protein -
CEG15_RS16975 637063..637431 + 369 WP_088729622.1 VOC family protein -
CEG15_RS16980 637592..638098 + 507 WP_088729623.1 hypothetical protein -
CEG15_RS16985 638127..639086 - 960 WP_088729551.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 435402..647524 212122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10898.61 Da        Isoelectric Point: 4.6794

>T78439 WP_045569735.1 NZ_CP022100:c634530-634252 [Vibrio anguillarum]
MIFWEEASLNDREKIFEFLYDFNPTAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T78439 NZ_CP022100:c634530-634252 [Vibrio anguillarum]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGAGAGAAAATTTTCGAATTTCTTTACGACTTTAACCCAACCGCAGC
TGAAAAAACGGATGAGCTCATAGAAACAAAAGTTGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGTA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT78439 WP_000381183.1 NZ_CP022100:c634811-634527 [Vibrio anguillarum]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT78439 NZ_CP022100:c634811-634527 [Vibrio anguillarum]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGTTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2I776

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References