Detailed information of TA system TA078438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 618429..618976
• Replicon: chromosome
• Accession: NZ_CP022100
• Organism: Vibrio anguillarum strain S3 4/9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEG15_RS16815
• Protein ID: WP_000818171.1
• Coordinates: 618674..618976 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: CEG15_RS16810
• Protein ID: WP_000861987.1
• Coordinates: 618429..618686 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEG15_RS16780	615367..615873	+	507	WP_064626873.1	GNAT family N-acetyltransferase	-
CEG15_RS16785	616015..616614	+	600	WP_064626922.1	pentapeptide repeat-containing protein	-
CEG15_RS16790	616637..616729	+	93	WP_198302711.1	DUF3265 domain-containing protein	-
CEG15_RS16795	617216..617725	+	510	WP_064626923.1	ClbS/DfsB family four-helix bundle protein	-
CEG15_RS16800	617716..617832	+	117	WP_088729816.1	DUF3265 domain-containing protein	-
CEG15_RS16805	617860..618237	+	378	WP_064626924.1	HNH endonuclease	-
CEG15_RS16810	618429..618686	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEG15_RS16815	618674..618976	+	303	WP_000818171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEG15_RS16820	619727..619993	+	267	WP_104411116.1	hypothetical protein	-
CEG15_RS16825	620227..620670	+	444	WP_064626925.1	hypothetical protein	-
CEG15_RS16835	620804..621265	+	462	WP_064626927.1	GNAT family N-acetyltransferase	-
CEG15_RS16840	621417..621782	+	366	WP_064626928.1	VOC family protein	-
CEG15_RS16850	622966..623451	+	486	WP_088729617.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	435402..647524	212122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.57 Da
• Isoelectric Point: 4.8838

>T78438 WP_000818171.1 NZ_CP022100:618674-618976 [Vibrio anguillarum]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T78438 NZ_CP022100:618674-618976 [Vibrio anguillarum]
ATGGCTGAAATAGTTTGGACGGAACCAGCTCTATCCGATCTAAATGATATTGCTGAATACATAGCGCTTGAAAATGTCGT
AGCTGCTAAACAACTGGTGCAAACTATTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGACGCATTCCAC
CAGAACTAGAGCACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGCCGTGTTTTCTACAAGTATGATGATGCAAATGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT78438 WP_000861987.1 NZ_CP022100:618429-618686 [Vibrio anguillarum]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT78438 NZ_CP022100:618429-618686 [Vibrio anguillarum]
ATGAAAGTAGAACTTGTAACTTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACTAAAGAGCCAGT
ATTGATAACTGAGCATGGAAAGCCGTCAGCTTATCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTTTAGCAA
TCCTCGAAGGAATTGCTCGTGGTGAGCGAGCTCTAGCGGATGGCAAAGTAGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9