Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 579601..580166 Replicon chromosome
Accession NZ_CP022100
Organism Vibrio anguillarum strain S3 4/9

Toxin (Protein)


Gene name relE Uniprot ID A0A4U1W7G7
Locus tag CEG15_RS16490 Protein ID WP_053815743.1
Coordinates 579879..580166 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3NI65
Locus tag CEG15_RS16485 Protein ID WP_011080399.1
Coordinates 579601..579882 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEG15_RS16445 574820..575443 + 624 WP_064626866.1 DUF1349 domain-containing protein -
CEG15_RS16455 575606..576139 + 534 WP_193254775.1 adenylate kinase -
CEG15_RS16465 576280..576744 + 465 WP_088729597.1 ASCH domain-containing protein -
CEG15_RS16470 576914..577684 + 771 WP_088729508.1 alpha/beta hydrolase -
CEG15_RS16475 578286..578818 + 533 Protein_547 cysteine hydrolase -
CEG15_RS16480 579058..579306 + 249 WP_026028286.1 DUF3297 family protein -
CEG15_RS16485 579601..579882 + 282 WP_011080399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CEG15_RS16490 579879..580166 + 288 WP_053815743.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEG15_RS16495 580381..580728 + 348 WP_017042813.1 DUF3024 domain-containing protein -
CEG15_RS16505 580878..581363 + 486 WP_088729598.1 GNAT family N-acetyltransferase -
CEG15_RS19720 581354..581470 + 117 Protein_553 DUF3265 domain-containing protein -
CEG15_RS16515 582112..583206 + 1095 WP_088729599.1 nucleotidyltransferase family protein -
CEG15_RS16520 583191..583313 + 123 WP_088729831.1 DUF3265 domain-containing protein -
CEG15_RS16530 583894..584439 + 546 WP_064626911.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 435402..647524 212122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10961.60 Da        Isoelectric Point: 5.0872

>T78437 WP_053815743.1 NZ_CP022100:579879-580166 [Vibrio anguillarum]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTELLSSMPEMGRTVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Download         Length: 288 bp

>T78437 NZ_CP022100:579879-580166 [Vibrio anguillarum]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTCATTTCACTGGATAACCCAGTGGC
GGCAGAAAACTGGGTTAATGAGGTTTTCGATAAAACTGAACTACTCTCTAGTATGCCTGAAATGGGGCGAACGGTTCCTG
AACTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGAATCATTTATAGCCTCAGCCATGAAATTCGTGTC
CTCACTGTACGAAATTGTCGTCAAATGCTAACTGAAAGTGACGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT78437 WP_011080399.1 NZ_CP022100:579601-579882 [Vibrio anguillarum]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Download         Length: 282 bp

>AT78437 NZ_CP022100:579601-579882 [Vibrio anguillarum]
ATGAGCCGCATTCACTTTGATCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAGCAGAT
TAACGAAACTCGCAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCAGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTGGAGGAAATGCGTACTGCTGAAGCACAGCTAGCTTCAGGTTTAGGTGTTTCTAAT
GAAGATGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U1W7G7

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0MQY5

References