Detailed information of TA system TA078436

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 544358..544923
• Replicon: chromosome
• Accession: NZ_CP022100
• Organism: Vibrio anguillarum strain S3 4/9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CEG15_RS16255
• Protein ID: WP_088729575.1
• Coordinates: 544636..544923 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A191WAQ2
• Locus tag: CEG15_RS16250
• Protein ID: WP_064626918.1
• Coordinates: 544358..544639 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEG15_RS16210	539632..539988	+	357	WP_045570554.1	hypothetical protein	-
CEG15_RS16215	540154..540567	+	414	WP_088729569.1	RDD family protein	-
CEG15_RS16220	541179..541637	+	459	WP_088729570.1	hypothetical protein	-
CEG15_RS16225	541792..542070	+	279	WP_088729571.1	hypothetical protein	-
CEG15_RS16230	542085..542303	+	219	WP_088729572.1	hypothetical protein	-
CEG15_RS16235	542287..542415	+	129	WP_088729825.1	DUF3265 domain-containing protein	-
CEG15_RS16240	542912..543472	+	561	WP_064626877.1	DUF2726 domain-containing protein	-
CEG15_RS16245	543609..544145	+	537	WP_088729573.1	hypothetical protein	-
CEG15_RS16250	544358..544639	+	282	WP_064626918.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CEG15_RS16255	544636..544923	+	288	WP_088729575.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CEG15_RS16260	545079..545879	+	801	WP_157724223.1	hypothetical protein	-
CEG15_RS16270	546359..546469	+	111	WP_088729826.1	DUF3265 domain-containing protein	-
CEG15_RS16280	548597..549016	+	420	WP_088729579.1	GNAT family N-acetyltransferase	-
CEG15_RS16285	549154..549471	-	318	WP_020838906.1	CcdB family protein	-
CEG15_RS16290	549471..549716	-	246	WP_061051371.1	type II toxin-antitoxin system CcdA family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	523947..546303	22356
	-	inside	Integron	-	-	435402..647524	212122

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.63 Da
• Isoelectric Point: 5.0892

>T78436 WP_088729575.1 NZ_CP022100:544636-544923 [Vibrio anguillarum]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEAFDKTDLLGAMPEMGRMVPEMPYTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQQLTENDV

Nucleotide

• Length: 288 bp

>T78436 NZ_CP022100:544636-544923 [Vibrio anguillarum]
ATGAAAGTAGTTTGGTCACCTTTAGCGTTACAAAAACTCGGTGACGCTGCAGAGTTTATCGCTTTGGATAACCCATCAGC
AGCAGAAAAATGGGTAAATGAAGCTTTCGATAAAACGGATTTGCTTGGAGCAATGCCAGAAATGGGTCGCATGGTTCCTG
AGATGCCTTATACGAACTACCGTGAAATCATTTTTGGCCATTACCGTATTATCTATAGCCTGAGCCATGAAATTCGAGTT
TTAACCGTGCGTAATTGTCGTCAACAGCTCACAGAAAATGATGTGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10364.85 Da
• Isoelectric Point: 5.1548

>AT78436 WP_064626918.1 NZ_CP022100:544358-544639 [Vibrio anguillarum]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTSEAQLAAGLGVSN
EDARSQVLGRINK

Nucleotide

• Length: 282 bp

>AT78436 NZ_CP022100:544358-544639 [Vibrio anguillarum]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTATCTGAGTTTCGTGCTGGCGTTGCATCATTTATCAAACAAAT
CAATGAAACTCGTCGGCCATTGGTTATTACACAGCGAGGTAAAGGTGTAGCTGTGGTTCTTGACGTTGCAGAATATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTTCAGAAGCTCAATTAGCAGCAGGTTTAGGTGTATCAAAC
GAAGATGCTCGTTCTCAAGTATTAGGACGCATTAATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A191WAQ2