Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 524951..525489 | Replicon | chromosome |
| Accession | NZ_CP022100 | ||
| Organism | Vibrio anguillarum strain S3 4/9 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A7X8U0Q7 |
| Locus tag | CEG15_RS16100 | Protein ID | WP_019282621.1 |
| Coordinates | 524951..525250 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A223N3B0 |
| Locus tag | CEG15_RS16105 | Protein ID | WP_072609711.1 |
| Coordinates | 525247..525489 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CEG15_RS16065 | 520458..521099 | + | 642 | WP_088729556.1 | hypothetical protein | - |
| CEG15_RS16070 | 521183..521704 | + | 522 | WP_088729557.1 | GNAT family N-acetyltransferase | - |
| CEG15_RS16075 | 522472..522726 | + | 255 | WP_088729558.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| CEG15_RS16080 | 522719..522988 | + | 270 | WP_069509627.1 | Txe/YoeB family addiction module toxin | - |
| CEG15_RS16085 | 523177..523797 | + | 621 | WP_088729559.1 | hypothetical protein | - |
| CEG15_RS16090 | 523947..524720 | + | 774 | WP_088729560.1 | hypothetical protein | - |
| CEG15_RS16095 | 524803..524943 | + | 141 | WP_088729561.1 | DUF3265 domain-containing protein | - |
| CEG15_RS16100 | 524951..525250 | - | 300 | WP_019282621.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CEG15_RS16105 | 525247..525489 | - | 243 | WP_072609711.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| CEG15_RS16110 | 525573..525665 | + | 93 | WP_193784381.1 | DUF3265 domain-containing protein | - |
| CEG15_RS16115 | 525704..526210 | + | 507 | WP_157724208.1 | hypothetical protein | - |
| CEG15_RS16120 | 526324..526788 | + | 465 | WP_064626859.1 | ASCH domain-containing protein | - |
| CEG15_RS16125 | 526781..526903 | + | 123 | WP_081265636.1 | DUF3265 domain-containing protein | - |
| CEG15_RS16130 | 526946..527584 | + | 639 | WP_017045405.1 | hypothetical protein | - |
| CEG15_RS16135 | 527733..528269 | + | 537 | WP_017045526.1 | GNAT family N-acetyltransferase | - |
| CEG15_RS19715 | 528510..528725 | - | 216 | WP_157722372.1 | hypothetical protein | - |
| CEG15_RS16145 | 529500..529904 | + | 405 | WP_021705403.1 | DUF1801 domain-containing protein | - |
| CEG15_RS16150 | 530155..530403 | + | 249 | WP_026028286.1 | DUF3297 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 523947..546303 | 22356 | |
| - | inside | Integron | - | - | 435402..647524 | 212122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11662.38 Da Isoelectric Point: 9.8917
>T78435 WP_019282621.1 NZ_CP022100:c525250-524951 [Vibrio anguillarum]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA
Download Length: 300 bp
>T78435 NZ_CP022100:c525250-524951 [Vibrio anguillarum]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTCCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTCCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.91 Da Isoelectric Point: 4.2340
>AT78435 WP_072609711.1 NZ_CP022100:c525489-525247 [Vibrio anguillarum]
MAKNTSITLGEHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK
MAKNTSITLGEHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK
Download Length: 243 bp
>AT78435 NZ_CP022100:c525489-525247 [Vibrio anguillarum]
ATGGCTAAAAATACTAGCATCACTCTCGGCGAGCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAAAGAAAA
TGA
ATGGCTAAAAATACTAGCATCACTCTCGGCGAGCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAAAGAAAA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7X8U0Q7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A223N3B0 |