Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 524951..525489 Replicon chromosome
Accession NZ_CP022100
Organism Vibrio anguillarum strain S3 4/9

Toxin (Protein)


Gene name parE Uniprot ID A0A7X8U0Q7
Locus tag CEG15_RS16100 Protein ID WP_019282621.1
Coordinates 524951..525250 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A223N3B0
Locus tag CEG15_RS16105 Protein ID WP_072609711.1
Coordinates 525247..525489 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEG15_RS16065 520458..521099 + 642 WP_088729556.1 hypothetical protein -
CEG15_RS16070 521183..521704 + 522 WP_088729557.1 GNAT family N-acetyltransferase -
CEG15_RS16075 522472..522726 + 255 WP_088729558.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CEG15_RS16080 522719..522988 + 270 WP_069509627.1 Txe/YoeB family addiction module toxin -
CEG15_RS16085 523177..523797 + 621 WP_088729559.1 hypothetical protein -
CEG15_RS16090 523947..524720 + 774 WP_088729560.1 hypothetical protein -
CEG15_RS16095 524803..524943 + 141 WP_088729561.1 DUF3265 domain-containing protein -
CEG15_RS16100 524951..525250 - 300 WP_019282621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CEG15_RS16105 525247..525489 - 243 WP_072609711.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CEG15_RS16110 525573..525665 + 93 WP_193784381.1 DUF3265 domain-containing protein -
CEG15_RS16115 525704..526210 + 507 WP_157724208.1 hypothetical protein -
CEG15_RS16120 526324..526788 + 465 WP_064626859.1 ASCH domain-containing protein -
CEG15_RS16125 526781..526903 + 123 WP_081265636.1 DUF3265 domain-containing protein -
CEG15_RS16130 526946..527584 + 639 WP_017045405.1 hypothetical protein -
CEG15_RS16135 527733..528269 + 537 WP_017045526.1 GNAT family N-acetyltransferase -
CEG15_RS19715 528510..528725 - 216 WP_157722372.1 hypothetical protein -
CEG15_RS16145 529500..529904 + 405 WP_021705403.1 DUF1801 domain-containing protein -
CEG15_RS16150 530155..530403 + 249 WP_026028286.1 DUF3297 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 523947..546303 22356
- inside Integron - - 435402..647524 212122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.38 Da        Isoelectric Point: 9.8917

>T78435 WP_019282621.1 NZ_CP022100:c525250-524951 [Vibrio anguillarum]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T78435 NZ_CP022100:c525250-524951 [Vibrio anguillarum]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTCCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.91 Da        Isoelectric Point: 4.2340

>AT78435 WP_072609711.1 NZ_CP022100:c525489-525247 [Vibrio anguillarum]
MAKNTSITLGEHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLDSFISELDSEERK

Download         Length: 243 bp

>AT78435 NZ_CP022100:c525489-525247 [Vibrio anguillarum]
ATGGCTAAAAATACTAGCATCACTCTCGGCGAGCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCGATTCGTTTATCAGTGAACTAGATAGCGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A223N3B0

References