Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 468395..468905 Replicon chromosome
Accession NZ_CP022100
Organism Vibrio anguillarum strain S3 4/9

Toxin (Protein)


Gene name relB Uniprot ID A0A289GH26
Locus tag CEG15_RS15685 Protein ID WP_009836584.1
Coordinates 468642..468905 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7X5B7D9
Locus tag CEG15_RS15680 Protein ID WP_009836585.1
Coordinates 468395..468649 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CEG15_RS15645 463877..464296 + 420 WP_064626929.1 GNAT family N-acetyltransferase -
CEG15_RS15650 464303..464437 + 135 WP_081265623.1 DUF3265 domain-containing protein -
CEG15_RS15655 464917..465426 + 510 WP_064626923.1 ClbS/DfsB family four-helix bundle protein -
CEG15_RS15660 465417..465533 + 117 WP_088729816.1 DUF3265 domain-containing protein -
CEG15_RS15665 465569..466039 + 471 WP_047691184.1 GNAT family N-acetyltransferase -
CEG15_RS15670 467117..468085 - 969 WP_088729510.1 IS30 family transposase -
CEG15_RS15680 468395..468649 + 255 WP_009836585.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CEG15_RS15685 468642..468905 + 264 WP_009836584.1 Txe/YoeB family addiction module toxin Toxin
CEG15_RS15690 469070..469825 + 756 WP_157724210.1 hypothetical protein -
CEG15_RS15695 471432..472334 + 903 WP_198302703.1 hypothetical protein -
CEG15_RS15700 472994..473638 + 645 WP_088729513.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 467117..468085 968
- inside Integron - - 435402..647524 212122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10302.63 Da        Isoelectric Point: 8.8578

>T78432 WP_009836584.1 NZ_CP022100:468642-468905 [Vibrio anguillarum]
MSSRLLSWTDESWNDYVYWQTQDKKTLKRINKLITDAKRSPFEGIGKPEPLKENLSGFWSRRIDDANRLVYAVDDSAITI
ISCRYHY

Download         Length: 264 bp

>T78432 NZ_CP022100:468642-468905 [Vibrio anguillarum]
ATGAGTAGTCGTTTATTATCTTGGACTGATGAATCTTGGAATGATTATGTTTATTGGCAGACGCAAGACAAGAAAACACT
TAAACGTATAAATAAACTCATCACGGATGCTAAGCGTTCTCCTTTCGAGGGCATAGGTAAACCTGAGCCACTAAAAGAAA
ACTTATCTGGTTTTTGGTCGCGACGAATAGACGATGCGAATAGGTTAGTTTATGCGGTTGATGATAGTGCTATCACGATT
ATTTCTTGCCGTTATCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9462.65 Da        Isoelectric Point: 5.5802

>AT78432 WP_009836585.1 NZ_CP022100:468395-468649 [Vibrio anguillarum]
MRIVSFTEARNSLKSVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLHRSIAQFKAGKVSQRD
LIDE

Download         Length: 255 bp

>AT78432 NZ_CP022100:468395-468649 [Vibrio anguillarum]
ATGAGAATTGTATCTTTTACAGAAGCTAGAAATAGCTTGAAGAGCGTTTTGGATGCTGTTGTTAATGACGCAGATACAAC
CGTGATCACACGTCGTGATTCTGAAGATGCCGTTGTTATGTCACTGGATTATTACAATAGCTTAATGGAAACGGTTCATT
TACTTCGTTCTCCGGCAAATGCTGAGCACTTACATCGTTCAATTGCTCAATTTAAAGCGGGTAAGGTGAGCCAAAGAGAT
TTAATCGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A289GH26

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5B7D9

References